Synthesis and antimicrobial activity of some new pyrazole containing cyanopyridone derivatives

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dc.contributor.authorMalladi, S.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorPeethambar, S.K.
dc.contributor.authorGanesh, B.M.
dc.contributor.authorGoud, P.S.K.
dc.date.accessioned2026-02-05T09:35:19Z
dc.date.issued2012
dc.description.abstractA series of new 4,6-disubstituted-3-cyano-2-pyridone derivatives (4a-o) were synthesized. The structures of all target molecules (4a-o) have been confirmed by various spectral techniques and elemental analyses. The newly synthesized compounds were screened for antibacterial and antifungal activity and most of the compounds showed significant activity comparable with that of the standard drug. The results revealed that 4b, 4c, 4d, 4g, 4m, 4n and 4o showed good antibacterial activity towards all bacterial strains (Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa) when compared to standard drug streptomycin. Amongst all the compounds, 4c showed moderate antifungal activity against Aspergillus flavus. The acute toxicity study has also been carried out for biologically active compounds and the experimental studies revealed that compounds were safe up to 2000 mg/kg and no deaths of animals were recorded.
dc.identifier.citationDer Pharma Chemica, 2012, 4, 1, pp. 43-52
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/27012
dc.subject2 oxo 4 (3 phenyl 1h pyrazol 4 yl) 6 (thiophen 2 yl) 1,2 dihydropyridine 3 carbonitrile
dc.subject4 [3 (2,4 dichlorophenyl) 1h pyrazol 4 yl] 6 (naphthalen 1 yl) 2 oxo 1,2 dihydropyridine 3 carbonitrile
dc.subject4 [3 (2,4 dichlorophenyl)1h pyrazol 4 yl] 2 oxo 6 (thiophen 2 yl) 1,2 dihydropyridine 3 carbonitrile
dc.subject4 [3 (4 chlorophenyl) 1h pyrazol 4 yl] 6 (5 chlorothiopen 2 yl) 2 oxo 1,2 dihydropyridine 3 carbonitrile
dc.subject4 [3 (4 chlorophenyl) 1h pyrazol 4 yl] 6 (naphthalen 1 yl) 2 oxo 1,2 dihydropyridine 3 carbonitrile
dc.subject4 [3 (4 chlorophenyl)1h pyrazol 4 yl] 2 oxo 6 (thiophen 2 yl) 1,2 dihydropyridine 3 carbonitrile
dc.subject4 [3 (4 fluorophenyl) 1h pyrazol 4 yl] 6 (naphthalen 1 yl) 2 oxo 1,2 dihydropyridine 3 carbonitrile
dc.subject4 [3 (4 fluorophenyl)1h pyrazol 4 yl] 2 oxo 6 (thiophen 2 yl) 1,2 dihydropyridine 3 carbonitrile
dc.subject4 [3 (4 methoxyphenyl) 1h pyrazol 4 yl] 6 (naphthalen 1 yl) 2 oxo 1,2 dihydropyridine 3 carbonitrile
dc.subject4 [3 (4 methylphenyl) 1h pyrazol 4 yl] 6 (naphthalen 1 yl) 2 oxo 1,2 dihydropyridine 3 carbonitrile
dc.subject4 [3 (4 methylphenyl)1h pyrazol 4 yl] 2 oxo 6 (thiophen 2 yl) 1,2 dihydropyridine 3 carbonitrile
dc.subject4,6 disubstituted 3 cyano 2 pyridone derivative
dc.subject6 (5 chlorothiophen 2 yl) 2 oxo 4 (3 phenyl 1h pyrazol yl) 1,2 dihydropyridine 3 carbonitrile
dc.subject6 (5 chlorothiophen 2 yl) 4 [3 (4 fluorophenyl) 1h pyrazol 4 yl] 2 oxo 1,2 dihydropyridine 3 carbonitrile
dc.subject6 (5 chlorothiophen 2 yl) 4 [3 (4 methylphenyl) 1h pyrazol 4 yl] 2 oxo 1,2 dihydropyridine 3 carbonitrile
dc.subject6 (naphthalen 1 yl) 2 oxo 4 (3 phenyl 1h pyrazole 4 yl) 1,2 dihydropyridine 3 carbonitrile
dc.subjectpyrazole derivative
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantibacterial activity
dc.subjectantifungal activity
dc.subjectarticle
dc.subjectAspergillus flavus
dc.subjectbacterial strain
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectdrug safety
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectEscherichia coli
dc.subjectfungal strain
dc.subjectmale
dc.subjectnonhuman
dc.subjectPseudomonas aeruginosa
dc.subjectrat
dc.subjectStaphylococcus aureus
dc.subjecttoxicity testing
dc.titleSynthesis and antimicrobial activity of some new pyrazole containing cyanopyridone derivatives

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