An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition

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dc.contributor.authorBhat, S.I.
dc.contributor.authorDas, U.K.
dc.contributor.authorTrivedi, D.R.
dc.date.accessioned2020-03-31T06:51:38Z
dc.date.available2020-03-31T06:51:38Z
dc.date.issued2015
dc.description.abstractAn efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4-Disubstituted quinazolines have been synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X-ray analysis of isolated intermediate. 2014 HeteroCorporation.en_US
dc.identifier.citationJournal of Heterocyclic Chemistry, 2015, Vol.52, 4, pp.1253-1259en_US
dc.identifier.uri10.1002/jhet.2220
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/9878
dc.titleAn Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Conditionen_US
dc.typeArticleen_US

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