Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles

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dc.contributor.authorVijesh, A.M.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorPrabhu, V.
dc.contributor.authorAhmad, S.
dc.contributor.authorMalladi, S.
dc.date.accessioned2026-02-05T09:36:13Z
dc.date.issued2010
dc.description.abstractIn the present study a series of novel 2,4-disubstituted thiazole derivatives containing substituted pyrazole moiety was synthesized by the reaction of 3-Aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazone with 6-Bromo/H-3-(bromoacetyl)-2H-chromen-2-one/phenacyl chloride. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for their antibacterial studies against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The results revealed that compounds 7c, 8e, and 8f having 2,5-dichlorothiophene substituent and 8c, 8d having 2,4-dichlorophenyl substituent showed significant antibacterial activity against all tested microorganisms. © 2010 Elsevier Masson SAS. All rights reserved.
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2010, 45, 11, pp. 5460-5464
dc.identifier.issn2235234
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2010.07.048
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/27398
dc.subject3 (2 bromoacetyl) 2h chromen 2 one
dc.subject3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde [4 (2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone
dc.subject3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde [4 (2,4 dichlorophenyl) 1,3 thiazol 2 yl]hydrazone
dc.subject3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde [4 (6 bromo 2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone
dc.subject3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde thiosemicarbazone
dc.subject3 (2,5 dichloro 3 thienyl) 1h pyrazole 4 carbaldehyde [4 (2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone
dc.subject3 (2,5 dichloro 3 thienyl) 1h pyrazole 4 carbaldehyde [4 (2,4 dichlorophenyl) 1,3 thiazol 2 yl]hydrazone
dc.subject3 (2,5 dichloro 3 thienyl) 1h pyrazole 4 carbaldehyde [4 (6 bromo 2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone
dc.subject3 (2,5 dichloro 3 thienyl) 1h pyrazole 4 carbaldehyde thiosemicarbazone
dc.subject3 (biphenyl) 1h pyrazole 4 carbaldehyde [4 (2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone
dc.subject3 [4 (methylthio)phenyl] 1h pyrazole 4 carbaldehyde [4 (2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone
dc.subject3 [4 (methylthio)phenyl] 1h pyrazole 4 carbaldehyde [4 (2,4 dichlorophenyl) 1,3 thiazol 2 yl]hydrazone
dc.subject3 [4 (methylthio)phenyl] 1h pyrazole 4 carbaldehyde [4 (6 bromo 2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone
dc.subject3 [4 (methylthio)phenyl] 1h pyrazole 4 carbaldehyde thiosemicarbazone
dc.subject3 biphenyl 4 yl 1h pyrazole 4 carbaldehyde [4 (2,4 dichlorophenyl) 1,3 thiazol 2 yl]hydrazone
dc.subject3 biphenyl 4 yl 1h pyrazole 4 carbaldehyde thiosemicarbazone
dc.subject6 bromo 3 (2 bromoacetyl) 2h chromen 2 one
dc.subjectantiinfective agent
dc.subjectceftriaxone
dc.subjectthiazole derivative
dc.subjectunclassified drug
dc.subjectantibacterial activity
dc.subjectarticle
dc.subjectBacillus subtilis
dc.subjectcarbon nuclear magnetic resonance
dc.subjectcontrolled study
dc.subjectdrug synthesis
dc.subjectEscherichia coli
dc.subjectheteronuclear nuclear magnetic resonance
dc.subjectmass spectrometry
dc.subjectnonhuman
dc.subjectPseudomonas aeruginosa
dc.subjectStaphylococcus aureus
dc.subjectAnti-Bacterial Agents
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMass Spectrometry
dc.subjectMicrobial Sensitivity Tests
dc.subjectSpectrophotometry, Infrared
dc.subjectThiazoles
dc.titleSynthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles

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