Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents
No Thumbnail Available
Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
An efficient, microwave irradiated synthesis of novel chromeno[2,3-b]-pyrimidine derivatives was carried out. 2-Amino-3,4-dihydro-2H-chromene-3-carbonitrile was converted into imine using N,N-Dimethylacetaldehyde dimethylacetal to give the core intermediate, which was used for the preparation of chromenopyrimidine library, using acetic acid and different amine in microwave irradiation for 5 min. Structures of newly synthesized compounds were confirmed by spectral studies. Compound 6g was characterized by single crystal X-ray analysis. All the compounds were also screened for their anti-microbial activity. Few of the compounds are found to be potential antimicrobials. © 2010 Elsevier Masson SAS. All rights reserved.
Description
Keywords
2 amino 3,4 dihydro 2h chromene 3 carbonitrile, 2 imino 2h chromene 3 carbonitrile, 4 (4 chlorobenzyl) 5h chromeno [2,3 d]pyrimidine, 5h chromeno [2,3 d]pyrimidin 4 amine, acetic acid, amine, antiinfective agent, ceftriaxone, n (1 benzylpiperidin 4 yl) 5h chromeno[2,3 d]pyrimidine 4 amine, n (2,4 dichlorophenyl) 5h chromeno[2,3 d]pyrimidin 4 amine, n (2,5 dimethylphenyl) 5h chromeno[2,3 d]pyrimidin 4 amine, n (3 fluoro 4 methylphenyl) 5h chromeno[2,3 d]pyrimidin 4 amine, n (5 methyl 1,3 thiazol 2 yl) 5h chromeno[2,3 d]pyrimidin 4 amine, n 1 naphthyl 5h chromeno [2,3 d]pyrimidin 4 amine, n [2 methyl 4 (trifluoromethyl)phenyl] 5 chromeno[2,3 d]pyrimidin 4 amine, n benzyl 5h chromeno [2,3 d]pyrimidin 4 amine, n tricyclo[5.2.1.03,8]dec 1 yl 5h chromeno[2,3 d]pyrimidin 4 amine, n' (3 cyano 3,4 dihydro 2h chromen 2 yl) n,ndimethylimido formamide, pyrimidine derivative, unclassified drug, antimicrobial activity, article, controlled study, drug potency, drug screening, drug synthesis, microwave irradiation, nonhuman, spectroscopy, structure activity relation, X ray analysis, Anti-Infective Agents, Bacteria, Benzopyrans, Pyrimidines
Citation
European Journal of Medicinal Chemistry, 2010, 45, 6, pp. 2695-2699