Synthesis and biological evaluation of aminoketones

dc.contributor.author	Sankappa, Rai, U.
dc.contributor.author	Isloor, A.M.
dc.contributor.author	Shetty, P.
dc.contributor.author	Isloor, N.
dc.contributor.author	Malladi, S.
dc.contributor.author	Fun, H.-K.
dc.date.accessioned	2020-03-31T08:45:23Z
dc.date.available	2020-03-31T08:45:23Z
dc.date.issued	2010
dc.description.abstract	A three-component Mannich reaction of different ketones with aromatic aldehydes and different amines in microwave irradiation under solvent free condition afforded corresponding ?-amino carbonyl compounds in excellent yields. This method proved as a novel and improved modification of the reported three-component Mannich reaction in terms of milder reaction conditions, reaction times, clean reaction profiles, very small quantity of catalyst and simple workup procedure. Newly synthesized ?-aminoketones were characterized by spectral studies. Structure of compound 4a was also confirmed by single-crystal X-ray analysis. All the compounds were screened for their antimicrobial activity by MIC method. Few of the molecules were found to be biologically potent. 2010 Elsevier Masson SAS. All rights reserved.	en_US
dc.identifier.citation	European Journal of Medicinal Chemistry, 2010, Vol.45, 12, pp.6090-6094	en_US
dc.identifier.uri	https://idr.nitk.ac.in/handle/123456789/13206
dc.title	Synthesis and biological evaluation of aminoketones	en_US
dc.type	Article	en_US

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