Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents

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dc.contributor.authorThomas, K.D.
dc.contributor.authorVasudeva Adhikari, A.V.
dc.contributor.authorTelkar, S.
dc.contributor.authorChowdhury, I.H.
dc.contributor.authorMahmood, R.
dc.contributor.authorPal, N.K.
dc.contributor.authorGuru Row, T.N.G.
dc.contributor.authorSumesh, E.
dc.date.accessioned2026-02-05T09:35:37Z
dc.date.issued2011
dc.description.abstractThree new series of 4-hydroxy-8-trifluoromethyl-quinoline derivatives were synthesized through multi step reactions. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of 5j was evidenced by X-ray crystallographic study. The newly synthesized title compounds were evaluated for their antimicrobial activities including antimycobacterial activity. Amongst the tested compounds, 5b, 5e, 5h, 5j, 6c and 7c displayed promising antimicrobial activity. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands, 5b, 5e, 5h, 5j and 6c. © 2011 Elsevier Masson SAS. All rights reserved.
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2011, 46, 11, pp. 5283-5292
dc.identifier.issn2235234
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2011.07.033
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/27160
dc.subject2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl n (4 methoxyphenyl)hydrazinecarboxamide
dc.subject2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl] n (4 methylphenyl)hydrazinecarbothioamide
dc.subject2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl] n (4 methylphenyl)hydrazinecarboxamide
dc.subject2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl] n (pyridin 3 yl)hydrazinecarbothioamide
dc.subject2 [[4 hydroxy 8 (trifluoromethyl)uinoline 3 yl]carbonyl] n (4 methoxyphenyl)hydrazinecarbothioamide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (1 methyl 1h benzotriazol 5 ylmethylene)hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (1 methyl 1h pyrrol 2 ylmethylene)hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (2 fluoro 4 methoxy benzylidene)hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (2 methylsulfanyl benzylidene)hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (3 hydroxy 4 methoxy benzylidene)hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (3h imidazol 4 ylmethylene)hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (4 methoxy benzylidene)hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (5 fluoro 2 hydroxy benzylidene)hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (5 methoxy 1h indol 3 ylmethylene)hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (5 methyl 3h imidazol 4 ylmethylene)hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (7 methyl 1h indol 3 ylmethylene)hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid [4 (1,1,2,2 tetrafluoro ethoxy) benzylidene]hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid benzo[1,2,5]oxadiazol 5 ylmethylene hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid benzofuran 5 ylmethylene hydrazide
dc.subject4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid pyridin 4 ylmethylene hydrazide
dc.subject4 hydroxy n' [(e) (4 methylphenyl)methylidene] 8 (trifluoromethyl)quinoline 3 carbohydrazide
dc.subjectacetic acid 4 [(4 hydroxy 8 trifluoromethyl quinoline 3 carbonyl)hydrazonomethyl] furan 2 ylmethylester
dc.subjecthydrazide derivative
dc.subjectn (2 fluorophenyl) 2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl]hydrazinecarbothioamide
dc.subjectn (3 chlorophenyl) 2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl]hydrazinecarbothioamide
dc.subjectn (3 chlorophenyl) 2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl]hydrazinecarboxamide
dc.subjectn (3,5 dimethylphenyl) 2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl]hydrazinecarboxamide
dc.subjectn (4 ethylphenyl) 2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl]hydrazinecarboxamide
dc.subjectquinoline derivative
dc.subjecttuberculostatic agent
dc.subjectunclassified drug
dc.subjectantimicrobial activity
dc.subjectarticle
dc.subjectdrug design
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectin vitro study
dc.subjectX ray crystallography
dc.subjectAntitubercular Agents
dc.subjectBacteria
dc.subjectDrug Design
dc.subjectHydrazines
dc.subjectMicrobial Sensitivity Tests
dc.subjectModels, Molecular
dc.subjectMolecular Conformation
dc.subjectQuinolines
dc.titleDesign, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents

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