Antimicrobial Metal-organic Frameworks

Abstract

Metal-organic frameworks (MOFs) belong to a 3D porous material, which is made of metal ions connected together by organic moieties (ligands). Also, it often underlies between coordination compounds and materials science. Owing to its highly porous structure and other functional properties such as high surface area and surface energy, it has been widely used in various applications, especially in electronics and biomedical sectors by tailor-made cations. MOF-based various substrates, including scaffolds, thin films, hydrogels, and 3D-printed structures showed remarkable improvement in various biological characteristics like cell differentiation, tissue regeneration, controlled drug release, and antimicrobial properties combined with mechanical stability. Antimicrobial MOFs are widely used for tissue regeneration as infections are the major reason for scaffolds or implants failure. This chapter deals only with various antimicrobial-based MOF substrates for a range of biomedical applications, such as tissue/organ regeneration, wound dressing materials, 3D-printed scaffolds, and drug delivery systems. © 2025 Wiley-VCH GmbH.