Synthesis of some new 2-(4-alkylthiophenoxy)-4-substituted-1, 3-thiazoles as possible anti-inflammatory and antimicrobial agents

Abstract

A series of new 2-{[4-(alkylthio)phenoxy]methyl}-4-substituted-1,3- thiazoles 4a-q, 6a-j have been synthesized from ethyl [4-(alkylthio)phenoxy] acetates 1a,b through multi-step reaction sequence. The structures of new compounds have been established on the basis of their elemental analysis and IR, 1H and 13C NMR and mass spectral data. Selected title compounds have been evaluated for anti-inflammatory activity and in vitro antibacterial testing against two pathogenic strains and antifungal screening against two fungi.