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Author: search.filters.author.Isloor, A.M.End date: 2009

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    Regioselective reaction: Synthesis, characterization and pharmacological studies of some new Mannich bases derived from 1,2,4-triazoles
    (2009) Isloor, A.M.; Kalluraya, B.; Shetty, P.
    In the present investigation, a series of new 4[(3-substituted-1H-pyrazol-4-yl)methyleneamino]-5-substituted-2-[(4-methylpiperzine-1-yl)methyl]-2H-1,2,4-triazole-3(4H)-thiones (4) were synthesized by the aminomethylation of 4-(3-substituted-1H-pyrazol-3-yl)methyleneamino-5-substituted-4H-1,2,4-triazole-3-thiols (3) with formaldehyde and N-methylpiperzine. These newly synthesized Schiff and Mannich bases were characterized by IR, 1H NMR, mass spectral data and elemental analyses. These compounds were screened for their antibacterial and antifungal activity. Some of the compounds were found to exhibit significant antimicrobial activity. 2009 Elsevier Masson SAS. All rights reserved.
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    Redetermination of methyl 3,4-O-isopropyl-idene-?-D-fucopyran-oside monohydrate
    (2009) Fun, H.-K.; Jebas, S.R.; Rai, S.; Shetty, P.; Isloor, A.M.
    In the title compound, C10H18O5 H2O, the fucopyran-oside ring adopts a chair conformation. The crystal packing is stabilized by inter-molecular O - H?O and C - H?O hydrogen bonds together with intra-molecular O?O [2.2936 (8) ] and inter-molecular O?O [2.7140 (8)-2.829 (3) ] short contacts. The mol-ecules are linked together to form an infinite chain along the a axis. This structure has been solved previously but with no R-values [Spiers (1931). Z. Kristallogr. Kristallgeom. Kristallphys. Kristallchem. 78, 101].
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    N-(1-Naphth-yl)-10H-9-oxa-1,3-diaza-anthracen-4-amine
    (2009) Fun, H.-K.; Chantrapromma, S.; Rai, S.; Shetty, P.; Isloor, A.M.
    In the mol-ecule of the title compound, C21H15N 3O, the 10H-9-oxa-1,3-diaza-anthracene ring system is slightly bent, with dihedral angles of 3.99 (6) and 4.80 (6) between the pyran ring and the pyrimidine and benzene rings, respectively. This ring system makes a dihedral angle of 85.23 (3) with the naphthalene plane. In the crystal packing, mol-ecules are linked by N - H?N hydrogen bonds into chains along the a axis and these chains are stacked along the b axis. The crystal is further stabilized by weak C - H?N and C - H?? inter-actions.
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    N,N-Bis(2,6-difluorobenzyl)-1,3,4-thia-diazol-2-amine
    (2009) Fun, H.-K.; Liew, W.-C.; Chandrakantha, B.; Isloor, A.M.
    In the title compound, C16H11F4N 3S, the dihedral angles between the thia-diazole ring and the difluorobenzyl rings are 81.95 (7) and 81.96 (7) , whereas the dihedral angle between the difluorobenzyl rings is 11.41 (7) . In the crystal structure, C - H?N and C - H?F inter-actions link the molecules into two-dimensional arrays parallel to the bc plane. Fun et al. 2009.
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    Ethyl 2-[(3-chloro-phen-yl)hydrazono]-3-oxobutanoate
    (2009) Fun, H.-K.; Padaki, M.; Sowmya; Isloor, A.M.; Chantrapromma, S.
    The mol-ecule of the title oxobutanoate derivative, C12H 13ClN2O3, adopts a keto-hydrazo tautomeric form and is roughly planar, the angle between the benzene ring and the mean plane through the hydrazone and aliphatic chain being 1.49 (6) . This planarity is further aided by the formation of an intra-molecular N - H?O hydrogen bond which generates an S(6) ring motif. The aromatic ring and aliphatic chain have a trans configuration with respect to the N - N bond. In the crystal packing, centrosymmetric R 2 2(16) dimers are formed through pairs of weak C - H?O(3-oxo) inter-actions. These dimers are linked together through weak C - H?O(carboxyl-ate C=O) inter-actions into ribbons along the b-axis direction. These ribbons are stacked along the a-axis direction. The crystal also exhibits Cl?Cl [3.4988 (6) ] and C?O [3.167 (2)-3.335 (2) ] short contacts.
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    Ethyl 2-[(2,6-dimethylphenyl)-hydrazono]-3-oxobutanoate
    (2009) Fun, H.-K.; Jebas, S.R.; Padaki, M.; Hegde, C.; Isloor, A.M.
    The title compound, C14H18N2O3, crystallizes with two independent molecules in the asymmetric unit, having closely comparable geometries. Both molecules are essentially planar [maximum deviations from the mean plane of 0.069 (1) and 0.068 (1) for the two molecules] and contain an intramolecular N?H?O hydrogen bond which generates a ring with graph-set motif S(6). In the crystal, the molecules are linked into chains along the c axis by intermolecular C?H?O hydrogen bonds, and intermolecular C?H?? interactions are also present.
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    Ethyl 2-[(4-chloro-phen-yl)hydrazono]-3-oxobutanoate
    (2009) Fun, H.-K.; Chantrapromma, S.; Padaki, M.; Radhika; Isloor, A.M.
    The mol-ecule of the title oxobutanoate derivative, C12H 13ClN2O3, is nearly planar; the inter-planar angle between the benzene ring and the mean plane through the hydrazono-3-oxobutanoate unit is 2.69 (3) . An intra-molecular N - H?O hydrogen bond generates an S(6) ring motif. In the crystal packing, C - H?O(3-oxo) inter-actions link mol-ecules into dimers. The dimers thus formed are linked through C - H?O(carboxyl-ate C=O) inter-actions, leading to the formation of ribbons along the [01 ] direction, which are stabilized via Cl?Cl [3.2916 (3) ] contacts. The ribbons are stacked via C?O contacts [3.2367 (12)-3.3948 (12) ].
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    Catena-Poly[[(ethanol-O)[3-(1-phenyl-1H-pyrazol-3-yl)benzoic acid-O]lithium] - 3-(1-phenyl-1H-pyrazol-3-yl)benzoato-2 O:O?]
    (2009) Fun, H.-K.; Balasubramani, K.; Rai, S.; Shetty, P.; Isloor, A.M.
    The asymmetric unit of the title polymeric compound, [Li2(C 16H11N2O2)2(C 16H12N2O2)2(CH 3CH2OH)2] n , contains two Li I ions, two 3-(1-phenyl-1H-pyrazol-3-yl)benzoate ions, two 3-(1-phenyl-1H-pyrazol-3-yl)benzoic acid molecules and two ethanol molecules. In the crystal structure, each of the two LiI ions has a distorted tetra-hedral geometry, coordinated by two carboxyl-ate O atoms, one carboxyl O atom and one ethanol O atom. The carboxyl-ate group bridges the LiI ions, forming a one-dimensional polymeric chain along [100]. The crystal structure is further stabilized by O - H?O and C - H?N hydrogen bonding, and ?-? inter-actions with centroid-centroid distances in the range 3.6534 (13)-3.8374 (13) . 2009 Fun et al.
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    4-(4-Fluoro-phen-oxy)benzoic acid
    (2009) Fun, H.-K.; Goh, J.H.; Rai, S.; Shetty, P.; Isloor, A.M.
    In the title compound, C13H9FO3, the dihedral angle between the two benzene rings is 70.99 (5) . In the crystal structure, molecules are linked into dimers by centrosymmetric O - H?O inter-actions, generating R 2 2(8) ring motifs. These dimers are linked into a two-dimensional array, parallel to the ab plane, by two different C - H?O inter-actions. A weak C - H?? inter-actions is also present. 2009 Fun et al.
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    (4-Chloro-2-fluoro-phen-yl)[1-(2,6-difluoro-phen-yl)but-3-en-yl]amine
    (2009) Fun, H.-K.; Rai, S.; Shetty, P.; Isloor, A.M.; Chantrapromma, S.
    In the mol-ecule of the title homoallylic amine, C16H 13ClF3N, the dihedral angle between the two benzene rings is 84.63 (4) . Weak intra-molecular N - H?F hydrogen bonds generate S(6) and S(5) ring motifs. In the crystal structure, weak inter-molecuar N - H?F hydrogen bonds link mol-ecules into centrosymmetric dimers which are arranged in mol-ecular sheets parallel to the ac plane.