Faculty Publications
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Item Transfer Learning Based Model for Colon Cancer Prediction Using VGG16(Institute of Electrical and Electronics Engineers Inc., 2023) Koppad, S.; Annappa, B.; Acharjee, A.Colon cancer, or a colorectal cancer, is a malignant neoplasm that originates in the colon. It is one of the most prevalent forms of cancer globally, with significant impacts on morbidity and mortality rates. The essential task is to detect it and detect it at an initial phase for curing the patient precisely. The artificial intelligence plays important roles in the colon cancer prediction. The authors proposed various models on colon cancer prediction using ML and DL. The existing approaches are unable to achieve good accuracy for the colon cancer prediction. This research work suggests a transfer learning based framework for the colon cancer prediction. This framework is planned on the basis of VGG16 and CNN in colon cancer prediction. The proposed framework is implemented in python and results is analysed concerning accuracy, precision, recall. © 2023 IEEE.Item Amidated pectin and gum Arabic aldehyde-based pH-sensitive hydrogel for targeted colonic treatment(Elsevier B.V., 2025) Singh, H.; JagadeeshBabu, J.; Mohan Balakrishnan, R.In this study, a novel pH-responsive hydrogel was developed by crosslinking amidated pectin(AmPec) with oxidised gum Arabic(GAA) by hydrogen and hemiacetal bonding without the need for toxic crosslinkers for oral delivery of doxorubicin to treat colon cancer. FTIR and NMR confirmed the amidation of pectin and oxidation of Gum Arabic. FTIR confirmed the formation of hydrogen and hemiacetal bonds in the hydrogel. X-ray diffraction(XRD) spectra showed the amorphous characteristic of AmPec-GAA hydrogels compared to their polymer precursors, confirming the formation of a crosslinked hydrogel. AmPec-GAA15 hydrogel swelled around 655 %±39.90 at pH 7.4 compared to 181 %±7.94 swelling at pH 1.2 after 72 h. The release of doxorubicin also followed the same trend, with only 4.48 % ±0.89 doxorubicin release at pH 1.2, while the drug release increased to 68.10 %±3.73 at pH 7.4 after 48 h. SEM micrographs revealed the macroporous and interconnected hydrogel structure with fewer pores in the hydrogel swelled in pH 1.2 compared with pH 7.4, where more visible pores were observed, indicating the pH-sensitive behaviour of the hydrogel. Hydrogel possessed excellent thermal and mechanical stability as revealed by TGA and rheology study, which can also be explored for tissue engineering applications. MTT assay on L929 cells showed cell viability above 95.1 %±,0.0074, demonstrating hydrogels' non-toxic and biocompatible behaviour. Meanwhile, Dox-loaded hydrogel induced higher cytotoxicity against HT-29 cells than free Dox in a dose-dependent manner. Therefore, the developed hydrogel can be used as an effective oral carrier to deliver doxorubicin to colon cancer while hindering its release in the stomach and thus preventing associated toxicity. © 2025 Elsevier B.V.