Faculty Publications
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Item Effective oxidation of alcohols by Iron(III)-Schiff base-triphenylphosphine complexes(2010) Rani, S.; Badekai Ramachandra, B.Iron(III)-Schiff base-triphenylphosphine complexes catalyze the oxidation of alcohols to their corresponding carbonyl compounds in presence of hydrogen peroxide in good yields. © 2010 Elsevier Ltd. All rights reserved.Item A catalyst- and solvent-free three-component reaction for the regioselective one-pot access to polyfunctionalized pyrroles(2013) Bhat, S.I.; Trivedi, D.R.A facile method for the regioselective synthesis of tetrasubstituted pyrroles, from readily accessible 1,3-dicarbonyls, benzoin derivatives and ammonium acetate, has been developed. The one-pot three-component reactions were performed to afford tetrasubstituted pyrroles under solvent- and catalyst-free conditions. © 2013 Elsevier Ltd. All rights reserved.Item Nano Fe3O4@APTES@Ni(OH)2 as a catalyst for alcohol oxidation(Royal Society of Chemistry, 2015) Bhat, P.B.; Badekai Ramachandra, B.R.A nanorod shaped nickel hydroxide coated ferrite nanocatalyst was synthesized by a traditional co-precipitation method. The particle size of the nanoferrite was tuned using a variable surfactant ratio to achieve a high surface area. A very high BET surface area (334.55 m2 g-1) was achieved for particles with sizes of 40-130 nm. The superparamagnetic reusable catalyst was found to be active for the selective liquid phase oxidation of alcohols with hydrogen peroxide as a mild oxidant. Nickel hydroxide acted as a Bronsted base working in synergy with the nanoferrite catalyst for alcohol oxidation. The catalytic system was found to catalyse primary and secondary alcohols efficiently (86%) to their corresponding carbonyls in good yields. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2015.Item Synthesis of cocrystals/salts of flucytosine: Structure and stability(Royal Society of Chemistry, 2018) Nechipadappu, S.K.; Ramachandran, J.; Naveen, N.; Lokanath, N.K.; Trivedi, D.R.5-Fluorocytosine or flucytosine (FLC) is a well-known drug for anti-fungal treatment and is one of the essential medicines needed in a health system. The main disadvantage of FLC drugs is their instability due to hydration under storage conditions. In the present work, cocrystal/salt screening experiments resulted in three molecular salts of FLC with dihydroxybenzoic acid derivatives, 2,3-dihydroxybenzoic acid (2,3HBA), 3,5-dihydroxybenzoic acid (3,5HBA), and 2,6-dihydroxybenzoic acid (2,6HBA), and two cocrystals with gallic acid (GAA) and glutaric acid (GLA). Since FLC drugs are highly susceptible to hydration, the present work concentrated on the stability of the synthesized molecular salts/cocrystals under different relative humidity (RH) conditions. All the newly formed crystalline adducts were characterized structurally, and the crystal structures were determined using single-crystal X-ray diffraction techniques (SCXRD). The FLC-2,6HBA salt was found to be a monohydrate, whereas the FLC-3,5HBA salt was crystallized as a hemipentahydrate. FLC-2,3HBA and FLC-GLA were crystallized in 2:1 equimolar ratios of FLC and the coformer. The FLC-GAA cocrystal crystallized in a 1:1 equimolar ratio. Two point heterosynthons between FLC and the coformer were observed in all the crystalline structures except FLC-GLA, where the structure was formed through a single point heterosynthon. Stability studies under different relative humidity conditions showed the non-hygroscopicity of the synthesized molecular salts/cocrystals. It was found that the FLC-2,3HBA salt, and the FLC-GAA and FLC-GLA cocrystals did not experience any hydration under the accelerated humidity conditions (both 70-75% RH and 90-95% RH) at ambient temperature (?30 °C). However, FLC-2,6HBA and FLC-3,5HBA were found to be hygroscopic under 70-75% RH conditions. Furthermore, all the synthesized salts/cocrystals except FLC-3,5HBA were found to be stable for 2 months under ambient conditions (?30 °C, 60-65% RH). Therefore, the FLC-2,3HBA salt, and the FLC-GAA and FLC-GLA cocrystals are better candidates for the preparation of new drug products of FLC. © 2018 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.Item Bioprospecting indigenous bacteria from landfill leachate for enhanced polypropylene microplastics degradation(Elsevier B.V., 2025) Dubey, A.P.; Thalla, A.K.Plastic pollution, especially microplastics (MPs), is a severe environmental threat. Due to the significant environmental issues posed by plastics, it is critical to use an effective and sustainable degradation technique. The study aimed to isolate and identify Indigenous bacterial strains from landfill leachate (LL) to evaluate its potential for degrading Polypropylene microplastics (PPMPs). The investigation identified two bacterial strains, Pseudomonas aeruginosa, and novel Staphylococcus haemolyticus, through 16S rRNA analysis, capable of decomposing PPMPs. Following a 30-day treatment period, it was noted that Staphylococcus haemolyticus reduced the dry weight of PPMPs by 25.46 % ± 1.35 %, whereas Pseudomonas aeruginosa strain reduced it by 7.01 % ± 0.85 %. Multiple tests, including weight loss, pH, optical density, total biomass yield, and BATH test of the medium, validated the growth of bacterial strains. The biochemical characteristics of the isolated strains were assessed through Biochemical tests. The study also investigated the surface, chemical, and structural changes in treated PPMPs using Scanning electron microscopy (SEM), Energy-Dispersive X-ray spectroscopy (EDS), X-ray diffractometer (XRD), and Ion Chromatography (IC) tests. The Fourier Transform Infrared Spectroscopy (FTIR) study also showed the creation of alcohol, methyl, as well as carbonyl groups due to hydrolysis and oxidation by both bacterial strains. This study implies that the Staphylococcus haemolyticus and Pseudomonas aeruginosa bacterial strains are secure and efficient for PPMP bioremediation. © 2025 Elsevier B.V.