Faculty Publications
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Publications by NITK Faculty
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Item A computational study on the stenosis circularity for a severe stenosed idealized artery(Pleiades journals, 2019) Prashantha, B.; Anish, S.Narrowing of blood vessels (stenosis) changes the nature of blood flow through the arteries. The altered flow structures at the downstream of stenosis may generate adverse effects on the arterial wall. Hence, an understanding of the effect of stenosis circularity on the flow behavior at the downstream of stenosis is clinically beneficial. The present study has been carried out on idealized stenosed artery model with severe case of stenosis (75% area reduction) but with the same cross-sectional area that has been selected for the study. The effect of different physiological states (pulse rates) study has been examined through using FLUENT Inc. solver by finite volume method, controlled through user-defined functions. The results indicate that the velocity profiles, oscillatory shear stress, and fluid residence time are significantly affected by the shape of the stenotic region. Fluid residence time in the downstream plays a significant role in understanding the hotspots for the secondary deposition/plaque. © Springer Nature Singapore Pte Ltd. 2019.Item State-of-the-art review on automated lumen and adventitial border delineation and its measurements in carotid ultrasound(Elsevier Ireland Ltd, 2018) Kumar, P.K.; Araki, T.; Rajan, J.; Laird, J.R.; Nicolaïdes, A.; Suri, J.S.Background and objective: Accurate, reliable, efficient, and precise measurements of the lumen geometry of the common carotid artery (CCA) are important for (a) managing the progression/regression of atherosclerotic build-up and (b) the risk of stroke. The image-based degree of stenosis in the carotid artery and the plaque burden can be predicted using the automated carotid lumen diameter (LD)/inter-adventitial diameter (IAD) measurements from B-mode ultrasound images. The objective of this review is to present the state-of-the-art methods and systems for the measurement of LD/IAD in CCA based on automated or semi-automated strategies. Further, the performance of these systems is compared based on various metrics for its measurements. Methods: The automated algorithms proposed for the segmentation of carotid lumen are broadly classified into two different categories as: region-based and boundary-based. These techniques are discussed in detail specifying their pros and cons. Further, we discuss the challenges encountered in the segmentation process along with its quantitative assessment. Lastly, we present stenosis quantification and risk stratification strategies. Results: Even though, we have found more boundary-based approaches compared to region-based approaches in the literature, however, the region-based strategy yield more satisfactory performance. Novel risk stratification strategies are presented. On a patient database containing 203 patients, 9 patients are identified as high risk patients, whereas 27 patients are identified as medium risk patients. Conclusions: We have presented different techniques for the lumen segmentation of the common carotid artery from B-mode ultrasound images and measurement of lumen diameter and inter-adventitial diameter. We believe that the issue regarding boundary-based techniques can be compensated by taking regional statistics embedded with boundary-based information. © 2018 Elsevier B.V.Item Effect of stenosis severity on wall shear stress based hemodynamic descriptors using multiphase mixture theory(Isfahan University of Technology secretary@jafmonline.net, 2018) Buradi, A.; Mahalingam, A.A variety of wall shear stress (WSS) based hemodynamic descriptors have been defined over the years to study hemodynamic flow instabilities as potential indicators or prognosticators of endothelial wall dysfunction. Generally, these hemodynamic indicators have been calculated numerically using 'single phase' approach. In single phase models, the flow-dependent cell interactions and their transport are usually neglected by treating blood as a single phase non- Newtonian fluid. In the present investigation, a multiphase mixture-theory model is used to define the motion of red blood cells (RBCs) in blood plasma and interactions between these two-components. The multiphase mixture theory model exhibited good agreement with the experimental results and performed better than non-Newtonian single phase model. The mixture-theory model is then applied to simulate pulsatile blood flow through four idealized coronary artery models having different degrees of stenosis (DOS) severities viz., 30, 50, 70 and 85% diameter reduction stenosis. The maximum WSS is seen at the stenosis throat in all the cases and maximum oscillatory shear index (OSI) is seen in downstream region of the stenosis. Our findings suggest that for degree of coronary stenosis more than 50%, a more disturbed fluid dynamics is observed downstream of stenosis. This could lead to further progression of stenosis and may promote a higher risk of atherogenesis and plaque buildup in the flow-disturbed area. The potential atherosclerotic lesion sites were identified based on clinically relevant values of WSS, timeaveraged WSS gradient (TAWSSG), time-averaged WSS (TAWSS), and OSI. Finally, the change in potential atherosclerotic lesion sites with respect to DOS has been quantified. © 2018, Isfahan University of Technology.Item Discrete-Phase Modelling of an Asymmetric Stenosis Artery Under Different Womersley Numbers(Springer Verlag, 2019) Prashantha, B.; Anish, S.Understanding the hemodynamics in the post-stenotic region of an asymmetric stenosis is of paramount importance in the study of atherosclerosis progression. Numerically, the analysis becomes more complex when a discrete phase is added to the continuous phase in order to understand the behaviour of atherogenic particles in a pulsatile flow environment. In the present study, discrete-phase modelling (DPM) of an asymmetric and symmetric stenosed artery models has been carried out at different Womersley numbers. The objective is to understand the correlation between the discrete-phase (atherogenic) particle behaviour with the characteristics of continuous phase (blood) under varying pulse frequencies. Continuous phase is modelled by time-averaged Navier–Stokes equations and solved by means of pressure implicit splitting of operators algorithm. DPM has been carried out with one-way coupling. The transport equations are solved in the Eulerian frame of reference, and the discrete phase is simulated in Lagrangian frame of reference. The study brings out the importance of helicity in the atherosclerosis progression. Result shows that the asymmetric stenosis model exhibits less helical flow structure and the vortical structures are not getting transported to the downstream. Consequently, the average particle residence time (PRT) of the atherogenic particles is one order higher than the symmetric stenosis model. Low PRT leads to enhanced mass transport in the arterial flow and triggers further occlusion/plaque build-up at the post-stenotic region. The extent of asymmetry in a diseased artery may be considered as a useful parameter in understanding the rate of progression of atherosclerosis. © 2018, King Fahd University of Petroleum & Minerals.