Faculty Publications

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Subject: search.filters.subject.Silica nanoparticles

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    Synthesis of silica hollow core shell nanoparticles by sacrificial nitrated polystyrene template approach for targeted drug delivery application
    (Elsevier Ltd, 2021) Deepika, D.; JagadeeshBabu, P.E.
    Silica hollow core shell nanoparticles (SHCNs) were synthesized by employing nitrated polystyrene as sacrificial template. Polystyrene (PS) nanoparticles were functionalized with nitro functional group to modify the surface properties and to enhance the pore size of SHCNs. Calcination of silica coated nitrated PS nanoparticles lead to the formation of SHCNs and no traces of the polymer particles were found inside SHCNs as analyzed in fourier transform infrared radiation (FTIR). Transmission electron microscope (TEM) images were used to analyze the shell thickness of silica which was tuned between 15 and 35 nm. Specific surface area and average pore sizes of SHCNs were found to vary from 533.6 to 130.5 m2/g and 2.6 to 3.7 nm respectively. SHCNs were loaded with doxorubicin to evaluate the potential release kinetics by varying the silica shell thickness and pH of the release medium. SHCNs showed sustained release for 250 min at a pH of 7.4. © 2021 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the International Conference on Advances in Materials Research - 2019.
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    Synthesis and characterization of microporous hollow core-shell silica nanoparticles (HCSNs) of tunable thickness for controlled release of doxorubicin
    (Springer Netherlands rbk@louisiana.edu, 2018) Deepika, D.; JagadeeshBabu, J.B.
    Hollow core-shell silica nanoparticles (HCSNs) are being considered as one of the most favorable drug carriers to accomplish targeted drug delivery. In the present study, we developed a simple two-step method, employing polystyrene (PS) nanoparticles (150 ± 20 nm) as a sacrificial template for the synthesis of microporous HCSNs of size 230 ± 30 nm. PS core and the wall structure directing agent cetyl trimethyl ammonium bromide (CTAB) were removed by calcination. Monodispersed spherical HCSNs were synthesized by optimising the parameters like water/ethanol volume ratio, PS/tetraethyl orthosilicate (TEOS) weight ratio, concentration of ammonia, and CTAB. Transmission electron microscopy (TEM) revealed the formation of hollow core-shell structure of silica with tunable thickness from 15 to 30 nm while tailoring the concentration of silica precursor. The results obtained from the cumulative release studies of doxorubicin loaded microporous HCSNs demonstrated the dependence of shell thickness on the controlled drug release behavior. HCSNs with highest shell thickness of 30 nm and lowest surface area of 600 m2/g showed delay in the doxorubicin release, proving their application as a drug carrier in targeted drug delivery systems. The novel concept of application of microporous HCSNs of pore size ~ 1.3 nm with large specific surface area in the field of drug delivery is successful. © 2018, Springer Nature B.V.
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    Sacrificial sulphonated polystyrene template-assisted synthesis of mesoporous hollow core-shell silica nanoparticles for drug-delivery application
    (Springer, 2020) Doddamani, D.; JagadeeshBabu, J.
    Spherical mesoporous hollow core-shell silica nanoparticles (HCSNs) of size 200 ± 50 nm with tunable thickness from 20 to 60 nm are synthesized using a sacrificial sulphonated polystyrene (PS, particle size 160 nm) template. A facile method is adopted for the sulphonation of PS using sulphuric acid, which enhanced the negative charge on the surface of PS as confirmed by zeta potential analysis and Fourier transform infrared radiation analysis. The thickness of the silica shell is tuned by altering the concentration of the silica precursor and is found to increase due to the use of the sulphonated PS template. N2 adsorption/desorption studies reported the variation of specific surface area of HCSNs from 644.1 to 197.8 m2 g?1 and average pore size from 1.55 to 3.4 nm. The drug release behaviour of HCSNs with different shell thicknesses is investigated using doxorubicin as the model drug. A delay in the drug release for ~300 min is successfully achieved by employing HCSNs with enhanced thickness of 60 nm. Application of HCSNs in targeted drug delivery was further supported by the in-vitro cytotoxicity studies carried out on lung adenocarcinoma cells. © 2020, Indian Academy of Sciences.