Faculty Publications

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    Synthesis of silica hollow core shell nanoparticles by sacrificial nitrated polystyrene template approach for targeted drug delivery application
    (Elsevier Ltd, 2021) Deepika, D.; JagadeeshBabu, P.E.
    Silica hollow core shell nanoparticles (SHCNs) were synthesized by employing nitrated polystyrene as sacrificial template. Polystyrene (PS) nanoparticles were functionalized with nitro functional group to modify the surface properties and to enhance the pore size of SHCNs. Calcination of silica coated nitrated PS nanoparticles lead to the formation of SHCNs and no traces of the polymer particles were found inside SHCNs as analyzed in fourier transform infrared radiation (FTIR). Transmission electron microscope (TEM) images were used to analyze the shell thickness of silica which was tuned between 15 and 35 nm. Specific surface area and average pore sizes of SHCNs were found to vary from 533.6 to 130.5 m2/g and 2.6 to 3.7 nm respectively. SHCNs were loaded with doxorubicin to evaluate the potential release kinetics by varying the silica shell thickness and pH of the release medium. SHCNs showed sustained release for 250 min at a pH of 7.4. © 2021 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the International Conference on Advances in Materials Research - 2019.
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    Isolation of Novel Aerobic denitrifier and optimization of process parameters for biological denitrification using RSM
    (Slovak University of Agriculture info@jmbfs.org, 2019) Joshi, K.; Navalgund, N.; Shet, V.B.; Srinikethan, G.; Ashwini; Sneha; Anusha; Aparna, A.
    The study aimed to isolate and characterize a high efficiency novel bacterium for denitrification in waste water and also to optimize process parameters under aerobic condition. One of the bacteria chosen among four, displayed a maximum of 98% reduction of nitrate. The strain was identified as Enterobacter sp. NCCP-29 by biochemical tests and further identified based on similarity of PCR-16S rRNA using universal primers. The parameters (pH, temperature, agitation speed, C:N ratio) which effect the denitrification were screened using one factor at a time. The pH, temperature and C:N ratio exhibited significant effect on the denitrification using Enterobacter sp. NCCP-29. The levels of these parameters were optimized using a central composite design (CCD). A maximum of 98% denitrification was achieved at pH 6.5, temperature 30°C and C: N ratio of 3:1. The second order model was generated and found to have a good fit with R2 value of 0.93. Investigations revealed the ability of Enterobacter sp. NCCP-29 to remove nitrate under aerobic conditions. © 2019, Slovak University of Agriculture.