Faculty Publications

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    Design, synthesis, characterization, and biological evaluation of novel pyrazine-1,3,4-oxadiazole/[1,2,4] triazolo[3,4-b][1,3,4]thiadiazine hybrids as potent antimycobacterial agents
    (Elsevier B.V., 2024) Naik, S.; Dinesha, P.; Udayakumar, U.; Shetty, V.P.; Deekshit, V.K.
    In this study, we present novel pyrazine-1,3,4-oxadiazole hybrids (T1-T9) and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives (T10-T18), which possess remarkable antimicrobial activity. These compounds have been meticulously scrutinized for their efficacy in combatting the M. tuberculosis H37Rv strain. Three compounds T7, T8, and T17 showed promising antitubercular activity with MIC of 1.56 µg/mL. The target compounds are also evaluated for their antibacterial activity against S. aureus, S. mutans, E. coli, and S. Typhi, and antifungal activity against A. niger. Most of the compounds showed significant antibacterial and antifungal activity. All the active compounds exhibited very low toxicity and none of the active compounds were toxic to the normal cells. To deepen our understanding of these compounds, an in-silico ADME, and molecular docking analysis against the DprE1 enzyme were conducted, followed by DFT studies to shed some light on their electronic properties, and enhance our grasp of their pharmacological potential. © 2024 Elsevier B.V.
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    A comprehensive review of radiation shielding concrete: Properties, design, evaluation, and applications
    (John Wiley and Sons Inc, 2025) Barbhuiya, S.; Das, B.B.; Norman, P.; Qureshi, T.
    This review paper provides a comprehensive analysis of radiation shielding concrete, covering its properties, design, evaluation, and applications. It begins with an introduction, stating the objective and scope. The paper explores radiation shielding basics, including ionizing radiation, shielding principles, and materials used for shielding. Concrete's properties relevant to shielding, radiation attenuation mechanisms, and factors affecting its efficiency are discussed. Different types of radiation shielding concrete are examined, along with their applications. The design and formulation of shielding concrete, including mix proportions, optimization techniques, and quality control, are presented. Evaluation methods and standards are discussed. Lastly, challenges, future directions, and emerging technologies are outlined. This review paper serves as a valuable resource for professionals involved in radiation shielding. The review on radiation shielding concrete highlighted its effectiveness in attenuating ionizing radiation, emphasizing material composition, density, and thickness as key design factors. Evaluation methods, such as gamma spectroscopy and Monte Carlo simulations, are discussed, demonstrating its versatile applications in nuclear facilities, healthcare, and space exploration. © 2024 The Author(s). Structural Concrete published by John Wiley & Sons Ltd on behalf of International Federation for Structural Concrete.