Faculty Publications
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Publications by NITK Faculty
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Item Role of graphene quantum dots synthesized through pyrolysis in the release behavior of temperature responsive poly (N,N-diethyl acrylamide) hydrogel loaded with doxorubicin(Taylor and Francis Inc. 325 Chestnut St, Suite 800 Philadelphia PA 19106, 2018) Havanur, S.; JagadeeshBabu, P.E.We have reported the synthesis and characterization of new drug carrier using Poly (N,N-diethyl acrylamide) (PDEA) and graphene quantum dots (GQDs). PDEA is a stimuli-responsive, macroporous polymer which has the ability to respond to change in surrounding temperature and addition of GQDs will help in improving the inherent characteristics of PDEA. In this research work, PDEA hydrogels along with GQDs have been synthesized by free radical polymerization. The effect of various concentrations of GQDs on the property of PDEA hydrogel was studied. The structural analysis of synthesized hydrogels was done using Fourier transform infrared spectroscopy (FT–IR). The internal surface morphology of porous hydrogels was observed using scanning electron microscope (SEM) micrographs. From the analysis, it has been observed that the equilibrium swelling ratio (ESR) and reswelling kinetics of the hydrogel significantly increased as the GQDs content was varied. The cancer drug (an anthracycline that is used for cancer chemotherapy) Doxorubicin (DOX) release behavior was studied and found that the performance of hydrogel is dependent on hydrogel composition, time, and surrounding temperature. The cytotoxicity of GQDs incorporated PDEA hydrogels gave a significant report which supports the potential application of hydrogel as an intelligent drug carrier. © 2018, © 2018 Taylor & Francis Group, LLC.Item Error analysis of Haar wavelet-based Galerkin numerical method with application to various nonlinear optimal control problems(Taylor and Francis Ltd., 2024) Madankar, S.R.; Setia, A.; M, M.; Vatsala, A.S.First, this paper defines a general nonlinear optimal control problem with state/control constraints and its approximation problem as the Haar wavelet Galerkin optimal control problem (HWGOCP). Then, a Haar wavelet-based Galerkin numerical method has been developed, which converts it to a nonlinear optimization problem. We theoretically prove that a Haar wavelet feasible solution of HWGOCP will exist. We also show that the approximate solutions of HWGOCP are consistent and converge to the optimal solution of the problem. A variety of application problems have been considered, which include optimal control of tumour growth using Chemotherapy drugs, optimal control of infection via the SIS model using treatment, the Brachistochrone problem in mechanics, optimal control of mold using a fungicide, optimal control of pH value of a chemical reaction to determine the quality of a product, etc. © 2024 Informa UK Limited, trading as Taylor & Francis Group.