Faculty Publications

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Substituted quinoline derivatives as potent biological agents
(Trans Tech Publications Ltd ttp@transtec.ch, 2014) Garudacharia, B.; Isloora, A.M.
Quinoline derivatives are the most promising class of active pharmaceutical agents compared with other heterocyclic compounds. Biological activity profile of quinoline can easily be controlled by introducing some active pharmacophore to the core ring. This chapter deals with the synthesis of quinoline derivatives and its biological activity. The enhancement of biological activity by incorporation of active functional group and effect of these functional groups were explained briefly. Main focus is given to the synthesis of different substituted quinoline derivatives for biological application with respect to the position on the quinoline core ring and modification of quinoline ring. © (2014) Trans Tech Publications, Switzerland.
Comprehensive insight into the extract optimization, phytochemical profiling, and biological evaluation of the medicinal plant Nothapodytes foetida
(Elsevier Ltd, 2022) Susanna, D.; Mohan Balakrishnan, R.M.; JagadeeshBabu, J.B.
Nothapodytes foetida is an endemic medicinal plant belonging to the family Icacinaceae from the deciduous forests of the Western Ghats. The extract yield, nutritional and phytochemical composition, metabolite profiling of N. foetida leaf extract has been analysed, along with the assessment of its antioxidant, anti-inflammatory, anti-microbial and anti-cancer potentialities. The effect of different extracting solvents and techniques was optimized to obtain maximum extract yield, and ultrasonication-assisted extraction with aqueous methanol as the solvent was chosen. Appreciable amounts of total phenolics (67.59 mg GAE/g DW), total flavonoids (24.75 mg QCE/g DW), and total tannins (55.67 mg GAE/g DW) were detected. FT-IR spectroscopy also confirmed the presence of alcohols, phenols, alkanes, amino acids, carboxylic acids, nitro compounds and amines in the extract. Further, GC-MS analysis detected the presence of 33 volatile compounds that comprised of viminalol, α, β-amyrins, β, γ-sitosterol, 9-methoxy-camptothecin, lupeols, and various di and tri terpenes in significant quantities. 1H NMR spectra revealed well-resolved signals for flavonoids, amino acids (trp, his, tyr, phe, ala, ile, gly, gln, thr, val) and organic acids. LC-MS analysis of the methanolic N. foetida extract depicted a higher polyphenolic content followed by the ethanolic and aqueous extracts. Additionally, the aqueous methanolic extract of N. foetida exhibited significant in-vitro antioxidant, anti-inflammatory, anti-microbial activity and anti-cancer activity. The overall results of this work ascertain the potency of N. foetida in nutraceutical and biomedical applications. © 2022
Biosurfactant Based Reverse Micellar Extraction of Lactoperoxidase from Whey: Exploitation of Rhamnolipid Characteristics for Back Extraction
(Taylor and Francis Ltd., 2023) Karanth, S.; Iyyaswami, R.; Raj, N.T.
Biosurfactant-based reverse micellar extraction of Lactoperoxidase (LP) was studied using Rhamnolipid (RL) as a biosurfactant. Different solvents were considered to select a suitable organic phase for forming reverse micelles (RM) to varying concentrations of RL for the extraction of LP from its synthetic aqueous solution. The effect of addition of nonionic surfactant as lipophilic linker, whey pH, and ionic strength of the whey was studied to improve the forward extraction of LP from acid whey. About 96.65% LP was extracted to the RM phase during forward extraction. Further, a new back extraction strategy was developed by harnessing the biosurfactant properties. The pH-specific protonation–deprotonation characteristic of the RL headgroups was exploited to overcome the back extraction of LP, which is the rate-limiting step. The back extraction in citrate buffer at pH 5 using 0.75 M KCl resulted in 85.71% active LP recovery with 8.4-fold purification. The effect of the extraction process on the antimicrobial activity of LP was further examined with S. aureus, and the multiplication of the organism was almost arrested even after 24 hr at 9°C. © 2023 Taylor & Francis Group, LLC.
Synthesis, Computational, and Photophysical Probing Interactions of Novel Isatin-Incorporated Thiazolyl-Coumarins as Potent Antitubercular Agents
(John Wiley and Sons Inc, 2025) Vinay, K.K.; Bodke, Y.D.; Naik, S.; Udayakumar, U.
In this work, we reported the synthesis of a novel series of isatin-incorporated thiazolyl-coumarin derivatives 4(a–h) by a one-pot three-component reaction of substituted isatin, thiosemicarbazide, and 3-(2-bromoacetyl) coumarin. The structures of the coumarin-thiazole scaffolds were precisely established by their IR, NMR, and HRMS spectral data. The UV–Vis absorption study of target molecules was investigated in six different solvents. Geometrical optimization, molecular electrostatic potential regions, and quantum chemical parameters were assessed using density functional theory (DFT) to explore the electronic properties of thiazolyl-coumarin derivatives. The synthesized compounds were screened for their in vitro antimycobacterial activity against Mycobacterium tuberculosis; all derivatives exhibited excellent antitubercular efficacy with MIC ? 3.25 µg/mL; among them, 4c and 4f were the most potent with a MIC of 1.56 µg/mL. Furthermore, in silico molecular docking analyses against the enoyl-ACP reductase (InhA) enzyme were conducted; all target ligands demonstrated favorable binding interactions within the active site of the InhA enzyme. © 2025 Wiley-VCH GmbH.

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