Faculty Publications

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Discomfort analysis in computerized numeric control machine operations
(Elsevier Science B.V., 2012) Muthukumar, K.; Sankaranarayanasamy, K.; Ganguli, A.K.
Objectives: The introduction of computerized numeric control (CNC) technology in manufacturing industries has revolutionized the production process, but there are some health and safety problems associated with these machines. The present study aimed to investigate the extent of postural discomfort in CNC machine operators, and the relationship of this discomfort to the display and control panel height, with a view to validate the anthropometric recommendation for the location of the display and control panel in CNC machines. Methods: The postural discomforts associated with CNC machines were studied in 122 male operators using Corlett and Bishop's body part discomfort mapping, subject information, and discomfort level at various time intervals from starting to end of a shift. This information was collected using a questionnaire. Statistical analysis was carried out using ANOVA. Results: Neck discomfort due to the positioning of the machine displays, and shoulder and arm discomfort due to the positioning of controls were identified as common health issues in the operators of these machines. The study revealed that 45.9% of machine operators reported discomfort in the lower back, 41.8% in the neck, 22.1% in the upper-back, 53.3% in the shoulder and arm, and 21.3% of the operators reported discomfort in the leg. Conclusion: Discomfort increased with the progress of the day and was highest at the end of a shift; subject age had no effect on patient tendency to experience discomfort levels. Copyright Â© 2012 by Safety and Health at Work (SH@W).
In vivo anticancer and histopathology studies of Schiff bases on Ehrlich ascitic carcinoma cells. 1st Cancer Update.
(2013) Dhanya, D.; Isloor, A.M.; Shetty, P.; Nayak, P.G.; Pai, K.S.R.
Three Schiff bases in two different concentrations were evaluated for their anti-tumor activity against Ehrlich ascites carcinoma (EAC) bearing Swiss albino mice. The in vivo anti-tumor potency of Schiff bases was assessed by measuring the increase in mean survival time of the drug treated over untreated control mice and treated standard (cisplatin) mice. Their toxicity was assessed in vivo in normal, standard, and EAC-bearing mice by measuring the drug-induced changes in biochemical as well as hematological parameters. The histopathology studies to assess the toxicity of these compounds on vital organs also have been studied. Among the three Schiff bases studied, 4-({[3-(4-fluorophenyl)-1. H-pyrazol-4-yl]methylene}amino)-5-[(2-methylphenoxy)methyl]-1,2,4-triazole-3-thiol (SB-3) at an optimal dose of 100. mg/kg body weight was found to enhance the mean survival time of infected mice. Deviated hematological parameters and mean survival time in tumor bearing mice were found to be significantly restored towards normal after treatment with SB-3 100. mg/kg body weight of mice. The ALP and SGOT values were found to approach the normal range. A:G ratios also did not deviate from normal on treatment with SB-3. The histopathology studies revealed only mild hepatotoxicity and nephrotoxicity when compared to the normal and standard. The splenic cellularity also did not show much variation from normal. SB-3 at a prime dose of 100. mg has shown promising anticancer activity in vivo against EAC when compared to standard drug with minimum toxic effects. © 2010 .
Development, optimization, and prototyping of a simplified sit-stand mechanism for lower limb impairments
(Springer Science and Business Media Deutschland GmbH, 2025) George, S.P.; Thomas, M.J.; Mathew, M.; Gangadharan, N.; Varghese, A.K.
A sit-stand device for rehabilitation should be simple in its design, easy to manufacture, and convenient for individuals with mobility impairments to use. This paper proposes a design framework and prototyping process for developing an assisted sit-to-stand mechanism tailored to the specific limitations faced by individuals with lower limb impairments. The study incorporates a functional kinematic and kinetic design to ensure the mechanism’s usability across a diverse range of individuals. Recognizing the critical challenges faced by individuals with spinal cord injuries (SCI) and subsequent paralysis, the design philosophy integrates considerations specifically aimed at this population. A simplified circular design trajectory is presented for individuals with muscle paralysis, focusing on the synthesis of an electrically actuated mechanism. A four-bar linkage is modeled to represent the mechanism in the sagittal plane. The functional attributes of the device are determined, and kinematic synthesis is performed to ensure comfort during the sit-to-stand motion. This is achieved by minimizing the actuator’s travel distance during the lift. The velocity and acceleration profiles of the linear actuator are determined after applying boundary conditions. An optimal configuration is selected based on minimizing the displacement of the electric actuator. A human body model based on a 50th percentile male was developed to simulate a motion study of the sit-stand and validate the trajectory using the motion study module in SOLIDWORKS™. An optimum sit-to-stand linkage design was synthesized, and the corresponding prototype was fabricated. The independent anthropometric dimensions on which the design depends are the thigh length and the weight. The sagittal linkages for lifting were calculated and tested through simulation with a human body model to replicate the sit-to-stand movement. The prototype was evaluated on an able-bodied individual. A key design feature was the repositioning of support from the armpit to the hip, thereby reducing user discomfort and improving ergonomics. The motion study revealed that the trajectory of the hip joint (H-point) followed a nearly circular curvature. Stability analysis using a mannequin confirmed a static stability margin of 1 and showed that the device would tip forward only if the deceleration exceeded 35.8 m/s2, which is significantly higher than typical human-induced accelerations—indicating safe operation during use. The prototype fabricated demonstrated the intended sit-to-stand functionality and validated the design approach. The motion analysis confirmed ergonomic hip support and smooth joint trajectories. While the initial testing was successful on an able-bodied subject, further evaluation involving individuals with spinal cord injuries is recommended for final adjustments. This work presents a cost-effective and customizable framework for manufacturing sit-to-stand assistive devices, scalable for variations in body weight and thigh length. © International Federation for Medical and Biological Engineering 2025.

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