Faculty Publications

Now showing 1 - 4 of 4

Synthesis and characterization of temperature sensitive P-NIPAM macro/micro hydrogels
(Elsevier B.V., 2011) JagadeeshBabu, P.E.; Suresh Kumar, R.; Maheswari, B.
A thermo responsive macro porous poly(N-isopropylacrylamide) hydrogel was synthesized using free radical polymerization. The reaction was optimized by varying the reaction temperature, monomer, cross-linker and initiator based on the strength and swelling characteristics of the hydrogel. The morphology of the macro hydrogel was observed using scanning electron microscope (SEM). The swelling behavior of the macro hydrogel was performed gravimetrically and found that the gel synthesized at 36 °C had maximum deswelling ratio of 34.5 (-). These optimized values were further used to synthesis micro hydrogels using water-oil (w/o) emulsion technique. The morphology of the micro hydrogels were observed through SEM. Effect of water-oil ratio and stirrer speed on the mean particle size of the micro hydrogels were studied. Micro hydrogels synthesized at 1:1.5. w/o ratio and at 800. rpm had perfect spherical shape and had least particle mean diameter of 0.74 ?m, with SD of 0.5. Dye release kinetics with respect to temperature and time were studied using methylene blue solution. The release kinetic studies of micro hydrogel showed higher sustained release for 56. h compared to the macro hydrogel. © 2011 Elsevier B.V.
Role of N-vinyl-2-pyrrolidinone on the thermoresponsive behavior of PNIPAm hydrogel and its release kinetics using dye and vitamin-B12 as model drug
(2014) Maheswari, B.; JagadeeshBabu, P.E.; Agarwal, M.
Temperature-sensitive hydrogels hold great promise in biological applications as they can respond to changes in physiological temperature to produce a desired effect like controlled drug delivery. In this study, a series of poly(N-isopropylacrylamide-co-N-vinyl-2-pyrrolidinone) thermosensitive hydrogels were synthesized by radical copolymerization of NIPAm with 1-vinyl-2-pyrrolidinone (NVP). By altering the initial NIPAm/NVP mole ratios, copolymers were synthesized to have their own distinctive lower critical solution temperature which was established using differential scanning calorimetry. The swelling behavior of the hydrogel was analyzed gravimetrically and it was observed that reswelling rate increases with increasing NVP mole ratio. Further characterizations of the hydrogels were performed using Fourier transform infrared spectroscopy and scanning electron microscopy. Release kinetics with respect to temperature was studied using methylene blue dye solution and vitamin B12. Kinetic modeling of the release profile revealed that the release mechanism is a non-Fickian diffusion mechanism. These results suggested that this material has potential application as intelligent drug carriers. The quantities of residual monomers in the PIV4 hydrogel were determined by HPLC method, and the results show almost complete conversion. © 2013 Taylor & Francis.
Synthesis of poly(styrene-co-methyl methacrylate) nanospheres by ultrasound-mediated Pickering nanoemulsion polymerization
(Springer Netherlands rbk@louisiana.edu, 2019) Buruga, K.; Kalathi, J.T.
Poly (styrene-co-methyl methacrylate) (PS-co-PMMA) nanospheres were synthesized by ultrasound-mediated Pickering nanoemulsion polymerization using halloysite nanotubes (HNTs) as a stabilizer. A relatively high conversion (? 99%) was obtained in a short span of time (60 min) relative to (?97%) for that obtained by conventional emulsion polymerization performed without ultrasound. The initial rate of polymerization and the conversion were found to be increasing with the acoustic intensity in the range of 12.5–25 W/cm2). The synthesized copolymer nanosphere particles exhibited a perfect spherical shape (from TEM analysis), good stability (from zeta-potential analysis), high molecular weight (Mw? 311 kDa from Gel permeation chromatography), and excellent thermal properties (Tg? 120°C from DSC and TGA) as a result of the combined physicochemical effects of acoustic cavitation. The formation of nanosized emulsion droplets stabilized by HNTs ultimately yielded nanospheres of PS-co-PMMA with an average size of ? 82.8 nm. The PS-co-PMMA nanospheres can have potential applications in medicine, dentistry, paper, paint, and automotive industries. © 2019, The Polymer Society, Taipei.
Poly(N,N-diethyl acrylamide)/functionalized graphene quantum dots hydrogels loaded with doxorubicin as a nano-drug carrier for metastatic lung cancer in mice
(Elsevier Ltd, 2019) Havanur, S.; Batish, I.; Cheruku, S.P.; Gourishetti, K.; JagadeeshBabu, J.; Kumar, N.
Cancer has emanated as a daunting menace to human-kind even though medicine, science, and technology has reached its zenith. Subsequent scarcity in the revelation of new drugs, the exigency of salvaging formerly discovered toxic drugs such as doxorubicin has emerged. The invention of drug carrier has made drug delivery imminent which is ascribable to its characteristic traits of specific targeting, effective response to stimuli and biocompatibility. In this paper, the nanoscale polymeric drug carrier poly(N,N-diethyl acrylamide) nanohydrogel has been synthesized by inverse emulsion polymerization. Lower critical solution temperature of the polymeric carrier has been modified using graphene quantum. The particle size of pure nanohydrogel was in the range of 47 to 59.5 nm, and graphene quantum dots incorporated nanohydrogels was in the range of 68.1 to 87.5 nm. Doxorubicin (hydroxyl derivative of anthracycline) release behavior as a function of time and temperature was analyzed, and the Lower critical solution temperature of the synthesized nanohydrogels has been found to be in the range of 28–42 °C. Doxorubicin release characteristics have improved significantly as the surrounding temperature of the release media was increased near to physiological temperature. Further, the cumulative release profile was fitted in the different kinetic model and found to follow a Fickian diffusion release mechanism. The hydrogel was assessed for its cytotoxicity in B16F10 cells by MTT assay. In-vivo studies were done to study the lung metastasis by melanoma cancer and the results showed a rational favorable prognosis which was confirmed by evaluating hematological parameters and the non-immunogenic nature of nanohydrogel by cytokine assay. Comprehensively, the results suggested that poly(N,N-diethyl acrylamide) nanohydrogels have potential application as an intelligent drug carrier for melanoma cancer. © 2019 Elsevier B.V.

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