Faculty Publications

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    Solid state amorphization of Mg-Zn-Ca system via mechanical alloying and characterization
    (Elsevier B.V., 2017) Manne, B.; Bontha, S.; Ramesh, M.R.; Krishna, M.; Balla, V.K.
    Magnesium based bulk metallic glasses have attracted significant attention of researchers due to better mechanical and corrosion properties when compared to their crystalline counterparts especially for biomedical applications. Scaling up the part size and production volumes of such materials through liquid metallurgy route is challenging. In this work amorphous Ca5Mg60+xZn35?x (X = 0, 3 and 7) alloys have been successfully synthesized through solid state amorphization using a high energy planetary ball mill. X-ray diffraction was used to identify the crystalline phases of the powder during reaction. Evolution of amorphous phase was analysed using a parameter involving the ratio of integral area of peaks to the integral area of background (IPB) obtained from XRD patterns. Results showed reaction time increases with decreasing Zn content in Ca5Mg60+xZn35?x (X = 0, 3 and 7) alloy to obtain maximum amorphous structure with a small amount of residual crystalline phase. Prolonged milling of these powders, to eliminate residual crystalline phases, resulted in the nucleation of Mg102.08Zn39.6 phase. The composition dependent characteristic temperatures and thermal stabilities were studied using differential scanning calorimetry. © 2016 The Society of Powder Technology Japan
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    Corrosion resistance and in-vitro bioactivity of BaO containing Na2O-CaO-P2O5 phosphate glass-ceramic coating prepared on 316 L, duplex stainless steel 2205 and Ti6Al4V
    (Institute of Physics Publishing helen.craven@iop.org, 2018) Edathazhe, A.B.; Shashikala, H.D.
    The phosphate glass with composition 11Na2O-15BaO-29CaO-45P2O5 was coated on biomedical implant materials such as stainless steel 316 L, duplex stainless steel (DSS) 2205 and Ti6Al4V alloy by thermal enamelling method. The structural properties and composition of glass coated substrates were studied by x-ray diffraction (XRD), Scanning electron microscopy (SEM) and Energy dispersive x-ray spectroscopy (EDS) analysis. The coatings were partially crystalline in nature with porous structure and pore size varied from micro to nanometer range. The polarization curve was obtained for uncoated and coated substrates from electrochemical corrosion test which was conducted at 37 °C in Hank's balanced salt solution (HBSS). The corrosion resistance of 316 L substrate increased after coating, whereas it decreased in case of DSS 2205 and Ti6Al4V. The XRD and SEM/EDS studies indicated the bioactive hydroxyapatite (HAp) layer formation on all the coated surfaces after electrochemical corrosion test, which improved the corrosion resistance. The observed electrochemical corrosion behavior can be explained based on protective HAp layer formation, composition and diffusion of ions on glass coated surfaces. The in-vitro bioactivity test was carried out at 37 °C in HBS solution for 14 days under static conditions for uncoated and coated substrates. pH and ion release rate measurements from the coated samples were conducted to substantiate the electrochemical corrosion test. The lower ion release rates of Na+ and Ca2+ from coated 316 L supported its higher electrochemical corrosion resistance among coated samples. Among the uncoated substrates, DSS showed higher electrochemical corrosion resistance. Amorphous calcium-phosphate (ACP) layer formation on all the coated substrates after in-vitro bioactivity test was confirmed by XRD, SEM/EDS and ion release measurements. The present work is a comparative study of corrosion resistance and bioactivity of glass coated and uncoated biomedical implants such as 316 L, DSS and Ti6Al4V. © 2018 IOP Publishing Ltd.
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    Surface design of Mg-Zn alloy temporary orthopaedic implants: Tailoring wettability and biodegradability using laser surface melting
    (Elsevier B.V., 2018) Manne, B.; Thiruvayapati, H.; Bontha, S.; Motagondanahalli Rangarasaiah, R.; Das, M.; Balla, V.K.
    Magnesium-based alloys have attracted significant attention for biomedical applications due to its biodegradability as well as density and elastic modulus which are close to those of human bone. However, the uncontrolled biodegradation and hydrogen evolution are of major concern. In this work, laser surface melting (LSM) has been carried out to tailor initial corrosion rates of Mg-2.2Zn alloy implants. Melt pool dimensions, microstructure and surface topography of the LSM samples were analysed. The wettability and in vitro degradation characteristics of untreated and treated alloy were compared. LSM resulted in much finer cellular microstructural features than as-cast alloy and the melted region depths between 65 and 115 ?m. Higher treatment depths helped to extend the corrosion protection time by suppressing the corrosion front movement. Polished LSM samples resulted in overall corrosion rates of 0.5–0.62 mm/year which was about 40%–50% reduction compared to the as-cast alloy. Accelerated biomineralisation of the surface via enhancements in the surface energy due to microstructural refinement as well as microstructural homogeneity and Zn enrichment in ?-Mg, favoured improvement of the overall corrosion performance of LSM-treated alloy. © 2018 Elsevier B.V.
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    Effect of zinc and rare-earth element addition on mechanical, corrosion, and biological properties of magnesium
    (Cambridge University Press, 2018) Kottuparambil, R.R.; Bontha, S.; Ramesh, M.R.; Arya, S.; Jana, A.; Das, M.; Balla, V.K.; Amrithalingam, S.; Prabhu, T.R.
    The present work aims to understand the effect of zinc and rare-earth element addition (i.e., 2 wt% Gd, 2 wt% Dy, and 2 wt% of Gd and Nd individually) on the microstructure evolution, mechanical properties, in vitro corrosion behavior, and cytotoxicity of Mg for biomedical application. The microstructure results indicate that the Mg-Zn-Gd alloy consists of the lamellar long period stacking ordered phase. The electrochemical and immersion corrosion behavior were studied in Hanks balanced salt solution. Enhanced corrosion resistance with reduced hydrogen evolution volume and magnesium (Mg2+) ion release were estimated for the Mg-Zn-Gd alloy as compared to the other two alloy systems. At the early stage of corrosion, formation of the oxide film inhibited the corrosion propagation. However, at the later stages, the breaking of the oxide film leads to shallow pitting mode of corrosion. The ultimate tensile strength of Mg-Zn-Gd-Nd is better than the other two alloys due to the uniform distribution of the Mg12Nd precipitate phase. The moderate strength in the Mg-Zn-Gd alloy is due to the low volume fraction of the secondary phase. The MTT (methylthiazoldiphenyl-tetrazolium bromide) assay study was carried out to understand the cell cytotoxicity on the alloy surfaces. Studies revealed that all three alloys had significant cellular adherence and no adverse effect on cells. © 2018 Materials Research Society.
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    Laser surface modification of Mg-Zn-Gd alloy: Microstructural, wettability and in vitro degradation aspects
    (Institute of Physics Publishing helen.craven@iop.org, 2018) Rakesh, K.R.; Bontha, S.; Ramesh, M.R.; Arya, S.; Das, M.; Balla, V.K.; Srinivasan, A.
    Mg-Zn-Gd have great potential for biomedical applications owing to excellent bioactivity and non-toxicity properties. In the present study, laser surface melting (LSM) was carried out on newly developed Mg-1Zn -2Gd (wt%) alloy. Effects of laser energy on microstructural evolution, corrosion properties, surface energy, and hardness have been investigated. The surface modified sample processed at different energy densities showed fine grain structure in the melt zone compared to the untreated substrate. Grain refinement in the laser melted region improved the hardness by 60%. The surface roughness was found to be increased with increasing laser energy density. At higher energy density, removal of materials from the surface is enhanced, resulting in deeper grooves and higher surface roughness. The wettability studies indicated that the variations in surface geometry, grain size and surface roughness of LSM samples strongly influence the surface energy and hydrophilicity. Improved wetting of LSM sample was achieved owing to grain refinement and low surface roughness. The corrosion resistance determined by immersion and electrochemical methods of laser melted sample in Hank's balanced salt solution improved considerably due to grain refinement, meltpool depth and uniform distribution of secondary phases. © 2018 IOP Publishing Ltd.
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    Highly fluorescent materials derived from ortho-vanillin: Structural, photophysical electrochemical and theoretical studies
    (Elsevier B.V., 2019) Poojary, S.; Acharya, M.; Abdul Salam, A.A.; Kekuda, D.; Nayek, U.; Madan Kumar, S.; Vasudeva Adhikari, A.V.; Dhanya, D.
    Small-molecule organic fluorophores are highly in demand attributed to their extensive prospective in material and biomedical applications. Particularly, luminescent ?-conjugated organic molecules that possess an efficient solid-state emission are excellent candidates for optoelectronic devices. Focusing on high demand of organic fluorophores, we herein report the synthesis of three organic fluorescent materials derived from o?vanillin, viz. an ester (F1), an azine (F2) and an azo dye (F3). Interestingly, F2 exhibited very intense luminescence in its aggregate phase due to the restriction in intra-molecular rotation (RIR), as demonstrated by solution thickening studies. Further, its Single Crystal X-ray Crystallography (SCXRD) study suggested the existence of various intra and inter molecular interactions and gave evidences for locked intra-molecular rotations of the benzene rings in the rigid conformation of the molecule. The bathochromic shift in fluorescence from solution to solid phase was confirmed by its thin-film emission spectrum, which evidences the formation of J-aggregates. The observed RIR, development of J-aggregates and high conjugation in F2 impart an excellent fluorescence in its aggregated state. Thin films of both F2 and F3 on ITO plates exhibited a bathochromic shift with a deep orange to red photoluminescence on UV excitation. Furthermore, the morphological characterization revealed the presence of clear dense grains in case of F2 and F3, while the DSC analysis indicated phase transitions of all the derivatives. As seen from dielectric measurement studies, the azo dye F3 exhibited the highest dielectric constant among the three derivatives. The electronic and photophysical data based on Density Functional Theory (DFT) and Time Dependent-DFT (TD-DFT) calculations are in agreement with the experimental results. All the above data clearly advocate that, the synthesized fluorophoric o?vanillin derivatives are excellent candidates for electro-optical devices. © 2018 Elsevier B.V.
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    Advanced machining of TiNiCo shape memory alloys for biomedical applications
    (ICE Publishing, 2019) Soni, H.; Ramesh, M.R.; Narendranath, S.
    Wire electro discharge machining (WEDM) is one of the most productive non-traditional machining processes. Complex shapes can be cut through the WEDM process. In the present study, attempts have been made to study the effects of various process parameters of WEDM such as pulse on time (Ton), pulse off time (Toff), servo voltage (SV), wire speed (WS) and servo feed (SF) on the material removal rate (MRR) and surface roughness (SR) for machining of TiNiCo shape memory alloys, traditionally used as bone staple material. Grey-relational-analysis-based entropy measurement methods were used for formulating a hybrid combination of optimisation methods, in order to investigate the input parameters of WEDM on the comprehensive performance of a bone staple material’s SR and MRR. Experiments were carried out by using response surface design (L-33), and the input parameters were ranked based on the grey relational grade. An experimental run was conducted using the optimal combination of input parameters of WEDM, which was obtained from the analysis. Ton of 125 µs, Toff of 42 µs, SV of 40 V, SF of 2180 machine units and WS of 4 m/min were obtained as the best combination of input process parameters for TiNiCo alloy. © 2019 ICE Publishing. All rights reserved.
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    Widely tunable low-pass gm ? C filter for biomedical applications
    (Institution of Engineering and Technology journals@theiet.org, 2019) Jayaram Reddy, J.R.M.; Laxminidhi, T.
    This study presents a fourth-order, low-pass Butterworth transconductor–capacitor gm ? C filter with tunable bandwidth for biomedical signal processing front-ends. An architecture has been proposed for realising very low transconductance values with tunability. This transconductor architecture makes it possible to realise a fully differential filter without the need for explicit common-mode feedback circuit. The filter has two tuning schemes, a resistor-based tuning (Rtuning) and a switched transconductor-based tuning (D-tuning). With R-tuning, the bandwidth is adjustable between 1 and 70 Hz and with D-tuning, the tuning range is 30 mHz–100 Hz. The filter has been designed in united microelectronics corporation (UMC) 0.18 µm complementary metal–oxide–semiconductor process. In terms of figure-of-merit, the proposed filter is found to be on par with the filters reported in the literature. © The Institution of Engineering and Technology 2018
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    Evaluation of wear resistance of magnesium/glass microballoon syntactic foams for engineering/biomedical applications
    (Elsevier Ltd, 2019) Manakari, V.; Parande, G.; Doddamani, M.; Gupta, M.
    Friction and wear behaviour of magnesium/glass microballoon (GMB) foams synthesized by Disintegrated Melt Deposition (DMD) were investigated under dry sliding conditions. The coefficient of friction (?) decreases with increasing GMB content. Mg-25wt.% GMB exhibits ?13% lower ? pure compared to magnesium. Wear resistance of magnesium showed a significant enhancement (?2.5 times) post GMB addition. Abrasion and oxidation were identified as dominant wear mechanisms post worn-surface analysis. Delamination wear, which has traditionally limited the advantages of composites with discontinuous reinforcements in sliding wear conditions for structural and biomedical applications can be effectively addressed by the development of these proposed syntactic foams. © 2019 Elsevier Ltd and Techna Group S.r.l.
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    Effect of low temperature annealing on the properties of nano Ni-Ti alloys
    (Institute of Physics Publishing helen.craven@iop.org, 2019) Mukunda, S.; Mahesh, M.; Narendranath, S.; Herbert, M.A.
    Binary 1:1 Ni-Ti alloy has been the work horse for many industrial and of late biomedical applications amongst all shape memory alloys. Apart from being employed for endovascular applications like stents and filters, they are also used as orthodontic braces and in endodontic tools. Ni-Ti drills and files are used in a few procedures with sterilization between uses. However, the effect of these sterilizing heat-treatments on the properties of the tools is not clearly investigated. In addition to this, satisfactory metallurgical explanations for the wear resistance of these alloys in absent in the literature. Therefore, this paper attempts to define the transformational temperatures for the Ni-Ti as-received and low temperature heat-treated conditions have been investigated using Differential Scanning Calorimetry (DSC). Attempts are made to justify their suitability for endodontic applications by evaluating their mechanical strength parameters using the Tensile and Wear tests. It was found that the samples showed did not show much variations in strength when subjected to tensile tests whereas the same was not observed for DSC tests. Ambient temperature x-ray diffraction studies indicate the presence of Austenitic and Martensitic phases in all the samples. DSC results are strongly affected by presence of internal stresses but stress-induced-martensitic forms in all the samples with equal facility. © 2019 IOP Publishing Ltd.