Faculty Publications
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Item Synthesis, characterization, and biological activity of metal complexes of 4-ethyl vanillideneamino-3-methyl-5-mercapto-1,2,4-triazole(2010) Ramasubramanian, A.S.; Badekai Ramachandra, B.; Ramakrishna, D.A series of transition metal-triazole derivatives have been synthesized and characterized by microanalytical, thermal, magneto-chemical, and spectral studies. The synthesized complexes were screened for biological activities. The complexes of Co(II) and Ni(II) emerged as a good antibacterial agent against Gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Bacillus subtilis, and Shigella flexneri. © 2010 Taylor & Francis.Item 1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: Synthesis, characterization and its biological studies(Royal Society of Chemistry, 2015) Harikrishna, N.; Isloor, A.M.; Kulal, K.; AlObaid, A.; Fun, H.-K.A new series 3-{2-[N?-(1,3-disubstituted-1H-pyrazol-4-yl-methylene)-hydrazino]-thiazol-4-yl}-chromen-2-one (10a-l) was synthesized by a multi-step reaction. All the synthesized compounds were characterized by IR, NMR, and mass spectral studies, followed by elemental analysis. The newly synthesized thiazole compounds were screened for their in vitro antibacterial and antifungal studies against various microorganisms. Antimicrobial studies carried out by the well diffusion method, showed a very good zone of inhibition for both bacteria (at a range of 20-50 mm diameter) and fungi (at a range of 10-30 mm diameter). Minimum Inhibitory Concentration (MIC) required for the 100% inhibition of bacteria and fungi was found to be as low as 15.6 ?g ml-1 for a few of the synthesized compounds. © The Royal Society of Chemistry 2015.