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Item A simple, rapid, selective and sensitive spectrophotometric method for the determination of palladium is proposed using piperonal thiosemicarbazone (PATS) as a reagent. The reagent forms a 1:2 complex (Pd:Reagent) with palladium. The yellow complex is soluble in 32-40% ethanol and has an absorption maximum at 363 nm. Beer's law is obeyed upto 3.85 ppm of palladium and the optimum concentration range is 0.5-2.45 ppm of Pd. The molar absorptivity and Sandell's sensitivity are 3. 80 x 104 dm3 mol-1 cm -1 and 2.8 x 10-3 ?g cm-2, respectively. The experimental conditions for complete colour development and the interference from various ions are investigated. The method is used for the determination of palladium in its complexes and synthetic mixtures.(Spectrophotometric determination of palladium(II) using piperonal thiosemicarbazone) Shetty, P.; Nityananda Shetty, A.N.; Gadag, R.V.2003Item Synthesis and anti-inflammatory evaluation of some new 3,6-disubstituted-1, 2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles bearing pyrazole moiety(2012) Malladi, S.; Isloor, A.M.; Shetty, P.; Fun, H.-K.; Telkar, S.; Mahmood, R.; Isloor, N.In the present study, a new series of 3,6-disubstituted- 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles (4aj) have been synthesized by condensing 3-substituted-4-amino-5- mercapto-1,2,4-triazoles (1a-b) with various 3-substitutedpyrazole- 4-carboxylic acids (3a-e) in the presence ofPOCl3. The structures of newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13CNMR, and mass spectroscopic studies. Structure of the compound 4b was also confirmed by recording the single crystal X-ray structure. All the synthesized compounds were screened for their anti-inflammatory activities by carrageenan induced paw edema method. Anti-inflammatory screening indicated that, compounds 4d, 4e, and 4h were found to be biologically active whereas remaining compounds showed poor antiinflammatory activity. Also molecular docking studies were also performed for compounds which showed good antiinflammatory activity. © Springer Science+Business Media, LLC 2011.