Faculty Publications
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Item Survey of Leukemia Cancer Cell Detection Using Image Processing(Springer Science and Business Media Deutschland GmbH, 2022) Devi, T.G.; Patil, N.; Rai, S.; Philipose, C.S.Cancer is the development of abnormal cells that divide at an abnormal pace, uncontrollably. Cancerous cells have the ability to destroy other normal tissues and can spread throughout the body. Cancer cells can develop in various parts of the body. The paper focuses on leukemia which is a type of blood cancer. Blood cancer usually start in the bone marrow where the blood is produced in the body. The types of blood cancer are: Leukemia, Non-Hodgkin lymphoma, Hodgkin lymphoma, and Multiple myeloma. Leukemia is a type of blood cancer that originates in the bone marrow. Leukemia is seen when the body produces an abnormal amount of white blood cells that hinder the bone marrow from creating red blood cells and platelets. Several detection methods to identify the cancerous cells have been proposed. Identification of the cancer cells through cell image processing is very complex. The use of computer aided image processing allows the images to be viewed in 2D and 3D making it easier to identify the cancerous cells. The cells have to undergo segmentation and classification in order to identify the cancerous tumours. Several papers propose segmentation methods, classification methods and some propose both. The purpose of this survey is to review various papers that use either conventional methods or machine learning methods to detect the cells as cancerous and non-cancerous. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.Item Real-time microscopy image-based segmentation and classification models for cancer cell detection(Springer, 2023) Devi, T.G.; Patil, N.; Rai, S.; Philipose, C.P.Image processing techniques and algorithms are extensively used for biomedical applications. Convolution Neural Network (CNN) is gaining popularity in fields such as the analysis of complex documents and images, which qualifies the approach to be used in biomedical applications. The key drawback of the CNN application is that it can’t call the previous layer output following the layer’s input. To address this issue, the present research has proposed the novel Modified U-Net architecture with ELU Activation Framework (MU-EAF) to detect and classify cancerous cells in the blood smear images. The system is trained with 880 samples, of which 220 samples were utilized in the validation model, and 31 images were utilized to verify the proposed model. The identified mask output of the segmentation model in the predicted mask fits the classification model to identify the cancer cell occurrence in the collected images. In addition, the segmentation evaluation is done by matching each pixel of the ground truth mask (labels) to the predicted labels from the model. The performance metrics for evaluating the segmentation of images are pixel accuracy, dice coefficient (F1-score), and Jaccard coefficient. Moreover, the model is compared with VGG-16 and simple modified CNN models, which have four blocks, each consisting of a convolutional layer, batch normalization, and activation layer with RELU activation function that are implemented and for assessing the same images used for the proposed model. The proposed model shows higher accuracy in comparison. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.