Faculty Publications
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Item Survey of Leukemia Cancer Cell Detection Using Image Processing(Springer Science and Business Media Deutschland GmbH, 2022) Devi, T.G.; Patil, N.; Rai, S.; Philipose, C.S.Cancer is the development of abnormal cells that divide at an abnormal pace, uncontrollably. Cancerous cells have the ability to destroy other normal tissues and can spread throughout the body. Cancer cells can develop in various parts of the body. The paper focuses on leukemia which is a type of blood cancer. Blood cancer usually start in the bone marrow where the blood is produced in the body. The types of blood cancer are: Leukemia, Non-Hodgkin lymphoma, Hodgkin lymphoma, and Multiple myeloma. Leukemia is a type of blood cancer that originates in the bone marrow. Leukemia is seen when the body produces an abnormal amount of white blood cells that hinder the bone marrow from creating red blood cells and platelets. Several detection methods to identify the cancerous cells have been proposed. Identification of the cancer cells through cell image processing is very complex. The use of computer aided image processing allows the images to be viewed in 2D and 3D making it easier to identify the cancerous cells. The cells have to undergo segmentation and classification in order to identify the cancerous tumours. Several papers propose segmentation methods, classification methods and some propose both. The purpose of this survey is to review various papers that use either conventional methods or machine learning methods to detect the cells as cancerous and non-cancerous. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.Item Image Analysis of Nuclei Histopathology Using Deep Learning: A Review of Segmentation, Detection, and Classification(Springer, 2023) Kadaskar, M.; Patil, N.Deep learning has recently advanced in its applicability to computer vision challenges, and medical imaging has become the most used technique in histopathology image analysis. Nuclei instance segmentation, detection, and classification are one such task. Reliable analysis of these image slides is critical in cancer identification, treatment, and care. Researchers have recently been interested in this issue. This study reviews the categorization and investigation of strategies utilized in recent works to improve the effectiveness of automated nuclei segmentation, detection, and classification in histopathology images. It critically examines state-of-the-art deep learning techniques, analyzes the trends, identifies the challenges, and highlights and helps with the future directions for research. The taxonomy includes deep learning techniques, enhancement, and optimization methods. The survey findings will help to overcome the challenges of nuclei segmentation, detection, and classification while improving the performance of models and, thus, aid future research plans. © 2023, The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd.Item ANet: Nuclei Instance Segmentation and Classification with Attention-Based Network(Springer, 2024) Kadaskar, M.; Patil, N.The segmentation and classification of nuclei in haematoxylin and eosin-stained images is critical for diagnosing cancer and other disorders. Developing automated methods is necessary for the quantitative analysis of whole-slide images and further downstream analysis. However, many challenges are to be solved, such as varying morphology and observer differences. To address these concerns, we present ANet, an encoder–decoder structure based on attention mechanisms for nuclear segmentation and classification that makes use of information in high-dimensional features improved by attention. These blocks generate meaningful feature activation and eliminate irrelevant information to produce finer maps. It segments the touching, clustered, and overlapping nuclei and classifies them using upsampling branches. Our method includes components such as PreAct-ResNet50, residual attention, convolutional block attention module, and dense attention unit. We demonstrate how our approach achieves cutting-edge performance on several multi-tissue histopathology datasets such as Kumar, CoNSeP, and CPM17. We also demonstrate our model’s generalization capabilities on other combinations of datasets, including CPM15 and TNBC. ANet demonstrates a notable improvement of 1.14%, 2.70%, 1.41%, and 1.29% in Dice, AJI, SQ, and PQ scores, respectively, for the CPM17 dataset. In addition, it achieves a 1.18% improvement in AJI score for the Kumar dataset. Despite the inherent challenges in nuclei classification within the CoNSeP dataset, ANet yields outstanding results, showcasing a substantial improvement of 9.74%, 3.97%, and 0.80% in F1 scores for the inflammatory, spindle, and miscellaneous classes. Furthermore, ANet exhibits strong generalization across the CPM dataset, TNBC, and Combined CoNSeP, with improvements observed in the majority of metrics. The given improvement is justifiable, as are the interpretable visual results. The proposed method is of great potential for analyzing histopathology images, demonstrated by an increment of performance in multiple metrics. © The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd 2024.