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Item Recent progress in in vivo studies and clinical applications of magnesium based biodegradable implants – A review(National Engg. Reaserch Center for Magnesium Alloys, 2021) Sekar, P.; Narendranath, N.; Desai, V.Biodegradable magnesium has regained great attention due to its ability to temporarily offer mechanical strength and degrade completely once the injured pathological tissue is healed. A few clinical applications of Mg-based implants were reported in the last century. However, the knowledge and experience is being gained continuously by studying the host response and degradation behavior of Mg implant in animal models and clinical trials. This led to the development of commercial products emerging from Europe and Asia very recently. The potential of Mg implants in repairing fractures at upper and lower limb of large, small animal models and humans is compared and discussed in detail. In addition the possible future Mg implants that might treat problems concerning to urology and gynecology are reviewed. © 2020Item Bio-corrosion impacts on mechanical integrity of ZM21 Mg for orthopaedic implant application processed by equal channel angular pressing(Springer, 2021) Sekar, P.; Nyahale, M.B.; Naik, G.M.; Narendranath, N.; Prabhu, A.; Rekha, P.D.The mechanical integrity of rolled ZM21 Mg was improved by equal channel angular pressing (ECAP) to function as a potential biodegradable bone screw implant. Electron backscattered diffraction (EBSD) revealed deformed grains of 45 µm observed in rolled ZM21 Mg. They were transformed to equiaxed fine grains of 5.4 µm after 4th pass ECAP. The yield strength of rolled and ECAPed ZM21 Mg alloys were comparable. In contrast, 4th pass ZM21 Mg exhibited relatively higher elongation when compared to rolled sample. The mechanical properties of rolled and ECAPed ZM21 Mg were dependant on both grain refinement and crystallographic texture. The rolled and 4th pass ECAPed tensile samples exhibited nonlinear deterioration of mechanical properties when tested after 7, 14, 21 and 28 days immersion in Hank’s solution. The evaluation signifies that regardless their processing condition, ZM21 Mg alloys are suitable for surgical areas that requires high mechanical strength. In addition, the 4th pass ECAP samples were viable to MG-63 cells proving themselves to be promising candidates for future in vivo studies. [Figure not available: see fulltext.] © 2021, The Author(s).