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Item LATA – Label attention transformer architectures for ICD-10 coding of unstructured clinical notes(Institute of Electrical and Electronics Engineers Inc., 2021) Mayya, V.; Kamath S․, S.S.; Sugumaran, V.Effective code assignment for patient clinical records in a hospital plays a significant role in the process of standardizing medical records, mainly for streamlining clinical care delivery, billing, and managing insurance claims. The current practice employed is manual coding, usually carried out by trained medical coders, making the process subjective, error-prone, inexact, and time-consuming. To alleviate this cost-intensive process, intelligent coding systems built on patients’ structured electronic medical records are critical. Classification of medical diagnostic codes, like ICD-10, is widely employed to categorize patients’ clinical conditions and associated diagnoses. In this work, we present a neural model LATA, built on Label Attention Transformer Architectures for automatic assignment of ICD-10 codes. Our work is benchmarked on the CodiEsp dataset, a dataset for automatic clinical coding systems for multilingual medical documents, used in the eHealth CLEF 2020-Multilingual Information Extraction Shared Task. The experimental results reveal that the proposed LATA variants outperform their basic BERT counterparts by 33-49% in terms of standard metrics like precision, recall, F1-score and mean average precision. The label attention mechanism also enables direct extraction of textual evidence in medical documents that map to the clinical ICD-10 diagnostic codes. © 2021 IEEE.Item Automated microaneurysms detection for early diagnosis of diabetic retinopathy: A Comprehensive review(Elsevier B.V., 2021) Mayya, V.; Kamath S․, S.S.; Kulkarni, U.Diabetic retinopathy (DR), a chronic disease in which the retina is damaged due to small vessel damage caused by diabetes mellitus, is one of the leading causes of vision impairment in diabetic patients. Detection of the earliest clinical sign of the advent of DR is a critical requirement for intervention and effective treatment. Ophthalmologists are trained to identify DR, based on examining specific minute changes in the eye - microaneurysms, retinal haemorrhages, macular edema and changes in the retinal blood vessels. Segmentation of microaneurysms (MA) is a critical requirement for the early diagnosis of DR and has been the primary focus of the research community over the past few years. In this work, a systematic review of existing literature is carried out to examine the diagnostic use of automated MA detection and segmentation for early DR diagnosis. We mainly focus on existing early DR diagnosis techniques to understand their strengths and weaknesses. Though early diagnosis is performed using colour fundus photography, fluorescein angiography or optical coherence tomography angiography images, our study is limited to colour fundus based techniques. The early DR diagnosis methodologies reviewed in this article can be broadly classified into classical image processing, conventional machine learning (ML), and deep learning (DL) based techniques. Though significant progress has been achieved in these three classes of early DR diagnosis, several challenges and gaps still exist, underscoring a considerable scope for the development of fully automated, user-friendly early DR diagnosis and grading systems. We discuss in detail the challenges that need to be addressed in designing such effective, efficient, and robust algorithms for early DR diagnosis systems and also the ample scope for future research in this area. © 2021