Faculty Publications

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Publications by NITK Faculty

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Author: search.filters.author.Malladi, S.Subject: search.filters.subject.antimicrobial activity

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    Synthesis and biological evaluation of aminoketones
    (2010) Sankappa Rai, U.; Isloor, A.M.; Shetty, P.; Isloor, N.; Malladi, S.; Fun, H.-K.
    A three-component Mannich reaction of different ketones with aromatic aldehydes and different amines in microwave irradiation under solvent free condition afforded corresponding ?-amino carbonyl compounds in excellent yields. This method proved as a novel and improved modification of the reported three-component Mannich reaction in terms of milder reaction conditions, reaction times, clean reaction profiles, very small quantity of catalyst and simple workup procedure. Newly synthesized ?-aminoketones were characterized by spectral studies. Structure of compound 4a was also confirmed by single-crystal X-ray analysis. All the compounds were screened for their antimicrobial activity by MIC method. Few of the molecules were found to be biologically potent. © 2010 Elsevier Masson SAS. All rights reserved.
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    Synthesis, characterization and antimicrobial activity of novel ethyl 1-(N-substituted)-5-phenyl-1H-pyrazole-4-carboxylate derivatives
    (2012) Chandrakantha, B.; Isloor, A.M.; Shetty, P.; Isloor, S.; Malladi, S.; Fun, H.-K.
    In the present study, a novel series of Pyrazole derivatives (3a-m) were synthesized by condensing ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2- enoate with different aromatic and aliphatic hydrazines. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral studies as well as by C, H, and N analyses. All the newly synthesized compounds were screened for their antibacterial properties against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. Among the screened samples, 3c, 3f, 3k, and 3l have showed excellent antibacterial activity against all the tested bacterial strains as compared to the standard drug Ceftriaxone. Few of the compounds were found to be biologically potent. Molecular structure of compound 3i was confirmed by single crystal X-ray analysis. © Springer Science+Business Media, LLC 2011.
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    Synthesis and evaluation of antioxidant, antimicrobial activities of new 2,4-disubstituted thiazoles
    (2012) Malladi, S.; Isloor, A.M.; Peethambar, S.K.; Shivananda, K.N.
    A new series of 2,4-disubstituted thiazole derivatives were synthesized by the reaction of various 3-aryl-1H-pyrazole-4- carbaldehyde thiosemicarbazones (2a-e) and phenacyl bromides. The compounds (3a-n) were characterized by IR, NMR, mass spectra and C, H, N analyses. All the synthesized compounds were screened for their antioxidant and antimicrobial activities. Antioxidant studies revealed that, compounds 3b, 3j and 3n showed significant scavenging activity whereas compounds 3e and 3n exhibited significant antimicrobial activity. The acute oral toxicity study for the compound 3e and 3n have revealed good safety profile till the uppermost dose (2000 mg/kg).