Faculty Publications
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Item Synthesis and characterization of temperature sensitive P-NIPAM macro/micro hydrogels(Elsevier B.V., 2011) JagadeeshBabu, P.E.; Suresh Kumar, R.; Maheswari, B.A thermo responsive macro porous poly(N-isopropylacrylamide) hydrogel was synthesized using free radical polymerization. The reaction was optimized by varying the reaction temperature, monomer, cross-linker and initiator based on the strength and swelling characteristics of the hydrogel. The morphology of the macro hydrogel was observed using scanning electron microscope (SEM). The swelling behavior of the macro hydrogel was performed gravimetrically and found that the gel synthesized at 36 °C had maximum deswelling ratio of 34.5 (-). These optimized values were further used to synthesis micro hydrogels using water-oil (w/o) emulsion technique. The morphology of the micro hydrogels were observed through SEM. Effect of water-oil ratio and stirrer speed on the mean particle size of the micro hydrogels were studied. Micro hydrogels synthesized at 1:1.5. w/o ratio and at 800. rpm had perfect spherical shape and had least particle mean diameter of 0.74 ?m, with SD of 0.5. Dye release kinetics with respect to temperature and time were studied using methylene blue solution. The release kinetic studies of micro hydrogel showed higher sustained release for 56. h compared to the macro hydrogel. © 2011 Elsevier B.V.Item Role of N-vinyl-2-pyrrolidinone on the thermoresponsive behavior of PNIPAm hydrogel and its release kinetics using dye and vitamin-B12 as model drug(2014) Maheswari, B.; JagadeeshBabu, P.E.; Agarwal, M.Temperature-sensitive hydrogels hold great promise in biological applications as they can respond to changes in physiological temperature to produce a desired effect like controlled drug delivery. In this study, a series of poly(N-isopropylacrylamide-co-N-vinyl-2-pyrrolidinone) thermosensitive hydrogels were synthesized by radical copolymerization of NIPAm with 1-vinyl-2-pyrrolidinone (NVP). By altering the initial NIPAm/NVP mole ratios, copolymers were synthesized to have their own distinctive lower critical solution temperature which was established using differential scanning calorimetry. The swelling behavior of the hydrogel was analyzed gravimetrically and it was observed that reswelling rate increases with increasing NVP mole ratio. Further characterizations of the hydrogels were performed using Fourier transform infrared spectroscopy and scanning electron microscopy. Release kinetics with respect to temperature was studied using methylene blue dye solution and vitamin B12. Kinetic modeling of the release profile revealed that the release mechanism is a non-Fickian diffusion mechanism. These results suggested that this material has potential application as intelligent drug carriers. The quantities of residual monomers in the PIV4 hydrogel were determined by HPLC method, and the results show almost complete conversion. © 2013 Taylor & Francis.