Faculty Publications
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Item Fully automatic ROI extraction and edge-based segmentation of radius and ulna bones from hand radiographs(PWN-Polish Scientific Publishers bbe@ibib.waw.pl, 2017) Simu, S.; Lal, S.; Nagarsekar, P.; Naik, A.Bone age is a reliable measure of person's growth and maturation of skeleton. The difference between chronological age and bone age indicates presence of endocrinological problems. The automated bone age assessment system (ABAA) based on Tanner and Whitehouse method (TW3) requires monitoring the growth of radius, ulna and short bones (phalanges) of left hand. In this paper, a detailed analysis of two bones in the bone age assessment system namely, radius and ulna is presented. We propose an automatic extraction method for the region of interest (ROI) of radius and ulna bones from a left hand radiograph (RUROI). We also propose an improved edge-based segmentation technique for those bones. Quantitative and qualitative results of the proposed segmentation technique are evaluated and compared with other state-of-the-art segmentation techniques. Medical experts have also validated the qualitative results of proposed segmentation technique. Experimental results reveal that these proposed techniques provide better segmentation accuracy as compared to the other state-of-the-art segmentation techniques. © 2017 Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of SciencesItem A Novel Adaptive Cuckoo Search Algorithm for Contrast Enhancement of Satellite Images(Institute of Electrical and Electronics Engineers, 2017) Suresh, S.; Lal, S.; Chintala, C.S.; Kiran, M.S.Owing to the increased demand for satellite images for various practical applications, the use of proper enhancement methods are inevitable. Visual enhancement of such images mainly focuses on improving the contrast of the scene procured, conserving its naturalness with minimum image artifacts. Last one decade traced an extensive use of metaheuristic approaches for automatic image enhancement processes. In this paper, a robust and novel adaptive Cuckoo search based Enhancement algorithm is proposed for the enhancement of various satellite images. The proposed algorithm includes a chaotic initialization phase, an adaptive Levy flight strategy and a mutative randomization phase. Performance evaluation is done by quantitative and qualitative results comparison of the proposed algorithm with other state-of-the-art metaheuristic algorithms. Box-and-whisker plots are also included for evaluating the stability and convergence capability of all the algorithms tested. Test results substantiate the efficiency and robustness of the proposed algorithm in enhancing a wide range of satellite images. © 2008-2012 IEEE.Item Multispectral satellite image denoising via adaptive cuckoo search-based wiener filter(Institute of Electrical and Electronics Engineers Inc., 2018) Suresh, S.; Lal, S.; Chen, C.; Çelik, T.Satellite image denoising is essential for enhancing the visual quality of images and for facilitating further image processing and analysis tasks. Designing of self-tunable 2-D finite-impulse response (FIR) filters attracted researchers to explore its usefulness in various domains. Furthermore, 2-D FIR Wiener filters which estimate the desired signal using its statistical parameters became a standard method employed for signal restoration applications. In this paper, we propose a 2-D FIR Wiener filter driven by the adaptive cuckoo search (ACS) algorithm for denoising multispectral satellite images contaminated with the Gaussian noise of different variance levels. The ACS algorithm is proposed to optimize the Wiener weights for obtaining the best possible estimate of the desired uncorrupted image. Quantitative and qualitative comparisons are conducted with 10 recent denoising algorithms prominently used in the remote-sensing domain to substantiate the performance and computational capability of the proposed ACSWF. The tested data set included satellite images procured from various sources, such as Satpalda Geospatial Services, Satellite Imaging Corporation, and National Aeronautics and Space Administration. The stability analysis and study of convergence characteristics are also performed, which revealed the possibility of extending the ACSWF for real-time applications as well. © 1980-2012 IEEE.Item NucleiSegNet: Robust deep learning architecture for the nuclei segmentation of liver cancer histopathology images(Elsevier Ltd, 2021) Lal, S.; Das, D.; Alabhya, K.; Kanfade, A.; Kumar, A.; Kini, J.R.The nuclei segmentation of hematoxylin and eosin (H&E) stained histopathology images is an important prerequisite in designing a computer-aided diagnostics (CAD) system for cancer diagnosis and prognosis. Automated nuclei segmentation methods enable the qualitative and quantitative analysis of tens of thousands of nuclei within H&E stained histopathology images. However, a major challenge during nuclei segmentation is the segmentation of variable sized, touching nuclei. To address this challenge, we present NucleiSegNet - a robust deep learning network architecture for the nuclei segmentation of H&E stained liver cancer histopathology images. Our proposed architecture includes three blocks: a robust residual block, a bottleneck block, and an attention decoder block. The robust residual block is a newly proposed block for the efficient extraction of high-level semantic maps. The attention decoder block uses a new attention mechanism for efficient object localization, and it improves the proposed architecture's performance by reducing false positives. When applied to nuclei segmentation tasks, the proposed deep-learning architecture yielded superior results compared to state-of-the-art nuclei segmentation methods. We applied our proposed deep learning architecture for nuclei segmentation to a set of H&E stained histopathology images from two datasets, and our comprehensive results show that our proposed architecture outperforms state-of-the-art methods. As part of this work, we also introduced a new liver dataset (KMC liver dataset) of H&E stained liver cancer histopathology image tiles, containing 80 images with annotated nuclei procured from Kasturba Medical College (KMC), Mangalore, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India. The proposed model's source code is available at https://github.com/shyamfec/NucleiSegNet. © 2020 Elsevier LtdItem LiverNet: efficient and robust deep learning model for automatic diagnosis of sub-types of liver hepatocellular carcinoma cancer from H&E stained liver histopathology images(Springer Science and Business Media Deutschland GmbH, 2021) Aatresh, A.A.; Alabhya, K.; Lal, S.; Kini, J.; Saxena, P.P.Purpose: Liver cancer is one of the most common types of cancers in Asia with a high mortality rate. A common method for liver cancer diagnosis is the manual examination of histopathology images. Due to its laborious nature, we focus on alternate deep learning methods for automatic diagnosis, providing significant advantages over manual methods. In this paper, we propose a novel deep learning framework to perform multi-class cancer classification of liver hepatocellular carcinoma (HCC) tumor histopathology images which shows improvements in inference speed and classification quality over other competitive methods. Method: The BreastNet architecture proposed by Togacar et al. shows great promise in using convolutional block attention modules (CBAM) for effective cancer classification in H&E stained breast histopathology images. As part of our experiments with this framework, we have studied the addition of atrous spatial pyramid pooling (ASPP) blocks to effectively capture multi-scale features in H&E stained liver histopathology data. We classify liver histopathology data into four classes, namely the non-cancerous class, low sub-type liver HCC tumor, medium sub-type liver HCC tumor, and high sub-type liver HCC tumor. To prove the robustness and efficacy of our models, we have shown results for two liver histopathology datasets—a novel KMC dataset and the TCGA dataset. Results: Our proposed architecture outperforms state-of-the-art architectures for multi-class cancer classification of HCC histopathology images, not just in terms of quality of classification, but also in computational efficiency on the novel proposed KMC liver data and the publicly available TCGA-LIHC dataset. We have considered precision, recall, F1-score, intersection over union (IoU), accuracy, number of parameters, and FLOPs as metrics for comparison. The results of our meticulous experiments have shown improved classification performance along with added efficiency. LiverNet has been observed to outperform all other frameworks in all metrics under comparison with an approximate improvement of 2 % in accuracy and F1-score on the KMC and TCGA-LIHC datasets. Conclusion: To the best of our knowledge, our work is among the first to provide concrete proof and demonstrate results for a successful deep learning architecture to handle multi-class HCC histopathology image classification among various sub-types of liver HCC tumor. Our method shows a high accuracy of 90.93 % on the proposed KMC liver dataset requiring only 0.5739 million parameters and 1.1934 million floating point operations per second. © 2021, CARS.Item Efficient deep learning architecture with dimension-wise pyramid pooling for nuclei segmentation of histopathology images(Elsevier Ltd, 2021) Aatresh, A.A.; Yatgiri, R.P.; Chanchal, A.K.; Kumar, A.; Ravi, A.; Das, D.; Raghavendra, B.S.; Lal, S.; Kini, J.Image segmentation remains to be one of the most vital tasks in the area of computer vision and more so in the case of medical image processing. Image segmentation quality is the main metric that is often considered with memory and computation efficiency overlooked, limiting the use of power hungry models for practical use. In this paper, we propose a novel framework (Kidney-SegNet) that combines the effectiveness of an attention based encoder-decoder architecture with atrous spatial pyramid pooling with highly efficient dimension-wise convolutions. The segmentation results of the proposed Kidney-SegNet architecture have been shown to outperform existing state-of-the-art deep learning methods by evaluating them on two publicly available kidney and TNBC breast H&E stained histopathology image datasets. Further, our simulation experiments also reveal that the computational complexity and memory requirement of our proposed architecture is very efficient compared to existing deep learning state-of-the-art methods for the task of nuclei segmentation of H&E stained histopathology images. The source code of our implementation will be available at https://github.com/Aaatresh/Kidney-SegNet. © 2021 Elsevier LtdItem High-resolution deep transferred ASPPU-Net for nuclei segmentation of histopathology images(Springer Science and Business Media Deutschland GmbH, 2021) Chanchal, A.K.; Lal, S.; Kini, J.Purpose: Increasing cancer disease incidence worldwide has become a major public health issue. Manual histopathological analysis is a common diagnostic method for cancer detection. Due to the complex structure and wide variability in the texture of histopathology images, it has been challenging for pathologists to diagnose manually those images. Automatic segmentation of histopathology images to diagnose cancer disease is a continuous exploration field in recent times. Segmentation and analysis for diagnosis of histopathology images by using an efficient deep learning algorithm are the purpose of the proposed method. Method: To improve the segmentation performance, we proposed a deep learning framework that consists of a high-resolution encoder path, an atrous spatial pyramid pooling bottleneck module, and a powerful decoder. Compared to the benchmark segmentation models having a deep and thin path, our network is wide and deep that effectively leverages the strength of residual learning as well as encoder–decoder architecture. Results: We performed careful experimentation and analysis on three publically available datasets namely kidney dataset, Triple Negative Breast Cancer (TNBC) dataset, and MoNuSeg histopathology image dataset. We have used the two most preferred performance metrics called F1 score and aggregated Jaccard index (AJI) to evaluate the performance of the proposed model. The measured values of F1 score and AJI score are (0.9684, 0.9394), (0.8419, 0.7282), and (0.8344, 0.7169) on the kidney dataset, TNBC histopathology dataset, and MoNuSeg dataset, respectively. ConclusionItem Development and evaluation of deep neural networks for the classification of subtypes of renal cell carcinoma from kidney histopathology images(Nature Research, 2025) Chanchal, A.K.; Lal, S.; Suresh, S.Kidney cancer is a leading cause of cancer-related mortality, with renal cell carcinoma (RCC) being the most prevalent form, accounting for 80–85% of all renal tumors. Traditional diagnosis of kidney cancer requires manual examination and analysis of histopathology images, which is time-consuming, error-prone, and depends on the pathologist’s expertise. Recently, deep learning algorithms have gained significant attention in histopathology image analysis. In this study, we developed an efficient and robust deep learning architecture called RenalNet for the classification of subtypes of RCC from kidney histopathology images. The RenalNet is designed to capture cross-channel and inter-spatial features at three different scales simultaneously and combine them together. Cross-channel features refer to the relationships and dependencies between different data channels, while inter-spatial features refer to patterns within small spatial regions. The architecture contains a CNN module called multiple channel residual transformation (MCRT), to focus on the most relevant morphological features of RCC by fusing the information from multiple paths. Further, to improve the network’s representation power, a CNN module called Group Convolutional Deep Localization (GCDL) has been introduced, which effectively integrates three different feature descriptors. As a part of this study, we also introduced a novel benchmark dataset for the classification of subtypes of RCC from kidney histopathology images. We obtained digital hematoxylin and eosin (H&E) stained WSIs from The Cancer Genome Atlas (TCGA) and acquired region of interest (ROIs) under the supervision of experienced pathologists resulted in the creation of patches. To demonstrate that the proposed model is generalized and independent of the dataset, it has experimented on three well-known datasets. Compared to the best-performing state-of-the-art model, RenalNet achieves accuracies of 91.67%, 97.14%, and 97.24% on three different datasets. Additionally, the proposed method significantly reduces the number of parameters and FLOPs, demonstrating computationally efficient with 2.71 × FLOPs & 0.2131 × parameters. © The Author(s) 2025.Item Multi head attention based deep learning framework for waxberry fruit object segmentation from high resolution remote sensing images(Nature Research, 2025) Vaghela, R.; Sravya, N.; Lal, S.; Sarda, J.; Thakkar, A.; Patil, S.In some Asian countries, waxberries are special fruit that demand substantial labour for harvesting each season. To ease this burden, automated fruit-picking equipment has seen extensive development over the past decade. However, accurately segmenting waxberries in orchards remains challenging due to complex environments with overlapping fruits, foliage occlusions, and variable lighting conditions. Most existing segmentation methods are optimized for controlled environments with steady lighting and unobstructed views of the fruit, which limits their effectiveness in real-world scenarios. This paper introduces a fully convolutional neural network namely Multi-Attention Waxberry Network (MAWNet) which effectively addresses challenges such as occlusions, overlapping fruits and variable lighting conditions. The MAWNet is a UNet based architecture and it consist of enhanced residual block, transformer block, Atrous Spatial Pyramid Pooling (ASPP) block and introduced Multiple Dilation Convolutional (MDC) Block. The experimental results validate that the proposed MAWNet model surpasses several State-of-the-Art (SOTA) architectures, in terms of performance with achieving a remarkable accuracy of 99.63%, an Intersection over Union (IoU) of 96.77%, and a Dice coefficient of 98.34%. © The Author(s) 2025.