Faculty Publications

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    NucleiSegNet: Robust deep learning architecture for the nuclei segmentation of liver cancer histopathology images
    (Elsevier Ltd, 2021) Lal, S.; Das, D.; Alabhya, K.; Kanfade, A.; Kumar, A.; Kini, J.R.
    The nuclei segmentation of hematoxylin and eosin (H&E) stained histopathology images is an important prerequisite in designing a computer-aided diagnostics (CAD) system for cancer diagnosis and prognosis. Automated nuclei segmentation methods enable the qualitative and quantitative analysis of tens of thousands of nuclei within H&E stained histopathology images. However, a major challenge during nuclei segmentation is the segmentation of variable sized, touching nuclei. To address this challenge, we present NucleiSegNet - a robust deep learning network architecture for the nuclei segmentation of H&E stained liver cancer histopathology images. Our proposed architecture includes three blocks: a robust residual block, a bottleneck block, and an attention decoder block. The robust residual block is a newly proposed block for the efficient extraction of high-level semantic maps. The attention decoder block uses a new attention mechanism for efficient object localization, and it improves the proposed architecture's performance by reducing false positives. When applied to nuclei segmentation tasks, the proposed deep-learning architecture yielded superior results compared to state-of-the-art nuclei segmentation methods. We applied our proposed deep learning architecture for nuclei segmentation to a set of H&E stained histopathology images from two datasets, and our comprehensive results show that our proposed architecture outperforms state-of-the-art methods. As part of this work, we also introduced a new liver dataset (KMC liver dataset) of H&E stained liver cancer histopathology image tiles, containing 80 images with annotated nuclei procured from Kasturba Medical College (KMC), Mangalore, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India. The proposed model's source code is available at https://github.com/shyamfec/NucleiSegNet. © 2020 Elsevier Ltd
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    O-SegNet: Robust Encoder and Decoder Architecture for Objects Segmentation from Aerial Imagery Data
    (Institute of Electrical and Electronics Engineers Inc., 2022) Eerapu, K.K.; Lal, S.; Narasimhadhan, A.V.
    The segmentation of diversified roads and buildings from high-resolution aerial images is essential for various applications, such as urban planning, disaster assessment, traffic congestion management, and up-to-date road maps. However, a major challenge during object segmentation is the segmentation of small-sized, diverse shaped roads, and buildings in dominant background scenarios. We introduce O-SegNet- the robust encoder and decoder architecture for objects segmentation from high-resolution aerial imagery data to address this challenge. The proposed O-SegNet architecture contains Guided-Attention (GA) blocks in the encoder and decoder to focus on salient features by representing the spatial dependencies between features of different scales. Further, GA blocks guide the successive stages of encoder and decoder by interrelating the pixels of the same class. To emphasize more on relevant context, the attention mechanism is provided between encoder and decoder after aggregating the global context via an 8 Level Pyramid Pooling Network (PPN). The qualitative and quantitative results of the proposed and existing semantic segmentation architectures are evaluated by utilizing the dataset provided by Kaiser et al. Further, we show that the proposed O-SegNet architecture outperforms state-of-the-art techniques by accurately preserving the road connectivity and structure of buildings. © 2017 IEEE.