Faculty Publications
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Item Structure and rheology of chitosan-nanohydroxyapatite composite hydrogel for soft tissue regeneration(American Institute of Physics Inc. subs@aip.org, 2020) Kumar, B.Y.S.; Isloor, A.M.; Periasamy, K.; Kumar, G.C.M.Chitosan (CS) hydrogels show desirable characteristics to use a soft tissue implants due to its biocompatibility, biodegradability and antimicrobial characteristics. However, the structural stability hinders its application in vivo. In the present work nanohydroxyapatite (HAp) was reinforced with chitosan hydrogel and to develop chitosan-hydroxyapatite (CS-HAp) composite hydrogel. The nanohydroxyapatite modifies the hydrogel network by promoting the secondary hydrogen bonds thereby enhances the mechanical stiffness. The elastic modulus could reach 10 kPa which is necessary for the proposed application. Overall, chitosan-hydroxyapatite composite hydrogels are the promising implant materials for next-generation soft tissue regeneration. © 2020 Author(s).Item Nanohydroxyapatite Reinforced Chitosan Composite Hydrogel with Tunable Mechanical and Biological Properties for Cartilage Regeneration(Nature Publishing Group Houndmills Basingstoke, Hampshire RG21 6XS, 2019) Kumar, B.Y.S.; Isloor, A.M.; Mohan Kumar, G.C.M.; Siddique, I.; Asiri, A.M.With the continuous quest of developing hydrogel for cartilage regeneration with superior mechanobiological properties are still becoming a challenge. Chitosan (CS) hydrogels are the promising implant materials due to an analogous character of the soft tissue; however, their low mechanical strength and durability together with its lack of integrity with surrounding tissues hinder the load-bearing application. This can be solved by developing a composite chitosan hydrogel reinforced with Hydroxyapatite Nanorods (HANr). The objective of this work is to develop and characterize (physically, chemically, mechanically and biologically) the composite hydrogels loaded with different concentration of hydroxyapatite nanorod. The concentration of hydroxyapatite in the composite hydrogel was optimized and it was found that, reinforcement modifies the hydrogel network by promoting the secondary crosslinking. The compression strength could reach 1.62 ± 0.02 MPa with a significant deformation of 32% and exhibits time-dependent, rapid self-recoverable and fatigue resistant behavior based on the cyclic loading-unloading compression test. The storage modulus value can reach nearly 10 kPa which is needed for the proposed application. Besides, composite hydrogels show an excellent antimicrobial activity against Escherichia coli, Staphylococcus aureus bacteria’s and Candida albicans fungi and their cytocompatibility towards L929 mouse fibroblasts provide a potential pathway to developing a composite hydrogel for cartilage regeneration. © 2019, The Author(s).