Faculty Publications
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Item Deep learning-based automated mitosis detection in histopathology images for breast cancer grading(John Wiley and Sons Inc, 2022) Mathew, T.; Ajith, B.; Kini, J.; Rajan, J.Cancer grade is an indicator of the aggressiveness of cancer. It is used for prognosis and treatment decisions. Conventionally cancer grading is performed manually by experienced pathologists via microscopic examination of pathology slides. Among the three factors involved in breast cancer grading (mitosis count, nuclear atypia, and tubule formation), mitotic cell counting is the most challenging task for pathologists. It is possible to automate this task by applying computational algorithms on pathology slides images. Lack of sufficiently large datasets and class imbalance between mitotic and non-mitotic cells in slide images are the two major challenges in developing effective deep learning-based methods for mitosis detection. In this paper, we propose a new approach and a method based on that to address these challenges. The high training data requirement of the advanced deep neural network is met by combining two datasets from different sources after a color-normalization process. Class imbalance is addressed by the augmentation of the mitotic samples in a context-preserving manner. Finally, a customized convolutional neural network classifier is used to classify the candidate cells into the target classes. We have used the publicly available datasets MITOS-ATYPIA and MITOS for the experiments. Our method outperforms most of the recent methods that are based on independent datasets and at the same time offers adaptability to the combination of datasets from different sources. © 2022 Wiley Periodicals LLC.Item Evolution of LiverNet 2.x: Architectures for automated liver cancer grade classification from H&E stained liver histopathological images(Springer, 2024) Chanchal, A.K.; Lal, S.; Barnwal, D.; Sinha, P.; Arvavasu, S.; Kini, J.Recently, the automation of disease identification has been quite popular in the field of medical diagnosis. The rise of Convolutional Neural Networks (CNNs) for training and generalizing medical image data has proven to be quite efficient in detecting and identifying the types and sub-types of various diseases. Since the classification of large datasets of Hematoxylin & Eosin (H&E) stained histopathology images by experts can be expensive and time-consuming, automated processes using deep learning have been encouraged for the past decade. This paper introduces LiverNet 2.x model by modifying the previously encountered LiverNet architecture. The proposed model uses two different improvements of the Atrous Spatial Pyramid Pooling (ASPP) block to extract the clinically defined features of hepatocellular carcinoma (HCC) from liver histopathology images. LiverNet 2.0 uses a modified form of ASPP block known as DenseASPP, where all the atrous convolution outputs are densely connected. Whereas LiverNet 2.1 uses fewer concatenations while maintaining a large receptive field by stacking the dilated convolutional blocks in a tree-like fashion. This paper also discusses the trade-off between LiverNet 2.0 and LiverNet 2.1 in terms of accuracy and computational complexity. All comparison model and the proposed model is trained and tested on the patches of two different histopathological datasets. The experimental results show that the proposed model performs better compared to reference models. For the KMC Liver dataset, LiverNet 2.0 and LiverNet 2.1 achieved an accuracy of 97.50% and 97.14% respectively. Accuracy of 94.37% and 97.14% for the TCGA Liver dataset are achieved. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.