Faculty Publications
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Item TAGS: Towards Automated Classification of Unstructured Clinical Nursing Notes(Springer Verlag service@springer.de, 2019) Gangavarapu, T.; Jayasimha, A.; S. Krishnan, G.S.; Kamath S․, S.K.Accurate risk management and disease prediction are vital in intensive care units to channel prompt care to patients in critical conditions and aid medical personnel in effective decision making. Clinical nursing notes document subjective assessments and crucial information of a patient’s state, which is mostly lost when transcribed into Electronic Medical Records (EMRs). The Clinical Decision Support Systems (CDSSs) in the existing body of literature are heavily dependent on the structured nature of EMRs. Moreover, works which aim at benchmarking deep learning models are limited. In this paper, we aim at leveraging the underutilized treasure-trove of patient-specific information present in the unstructured clinical nursing notes towards the development of CDSSs. We present a fuzzy token-based similarity approach to aggregate voluminous clinical documentations of a patient. To structure the free-text in the unstructured notes, vector space and coherence-based topic modeling approaches that capture the syntactic and latent semantic information are presented. Furthermore, we utilize the predictive capabilities of deep neural architectures for disease prediction as ICD-9 code group. Experimental validation revealed that the proposed Term weighting of nursing notes AGgregated using Similarity (TAGS) model outperformed the state-of-the-art model by 5% in AUPRC and 1.55% in AUROC. © 2019, Springer Nature Switzerland AG.Item Deep neural learning for automated diagnostic code group prediction using unstructured nursing notes(Association for Computing Machinery, 2020) Jayasimha, A.; Gangavarapu, T.; Kamath S․, S.; S. Krishnan, G.S.Disease prediction, a central problem in clinical care and management, has gained much significance over the last decade. Nursing notes documented by caregivers contain valuable information concerning a patient's state, which can aid in the development of intelligent clinical prediction systems. Moreover, due to the limited adaptation of structured electronic health records in developing countries, the need for disease prediction from such clinical text has garnered substantial interest from the research community. The availability of large, publicly available databases such as MIMIC-III, and advancements in machine and deep learning models with high predictive capabilities have further facilitated research in this direction. In this work, we model the latent knowledge embedded in the unstructured clinical nursing notes, to address the clinical task of disease prediction as a multi-label classification of ICD-9 code groups. We present EnTAGS, which facilitates aggregation of the data in the clinical nursing notes of a patient, by modeling them independent of one another. To handle the sparsity and high dimensionality of clinical nursing notes effectively, our proposed EnTAGS is built on the topics extracted using Non-negative matrix factorization. Furthermore, we explore the applicability of deep learning models for the clinical task of disease prediction, and assess the reliability of the proposed models using standard evaluation metrics. Our experimental evaluation revealed that the proposed approach consistently exceeded the state-of-the-art prediction model by 1.87% in accuracy, 12.68% in AUPRC, and 11.64% in MCC score. © 2020 Association for Computing Machinery.Item Predicting ICD-9 code groups with fuzzy similarity based supervised multi-label classification of unstructured clinical nursing notes(Elsevier B.V., 2020) Gangavarapu, T.; Jayasimha, A.; S. Krishnan, G.S.; Kamath S?, S.In hospitals, caregivers are trained to chronicle the subtle changes in the clinical conditions of a patient at regular intervals, for enabling decision-making. Caregivers’ text-based clinical notes are a significant source of rich patient-specific data, that can facilitate effective clinical decision support, despite which, this treasure-trove of data remains largely unexplored for supporting the prediction of clinical outcomes. The application of sophisticated data modeling and prediction algorithms with greater computational capacity have made disease prediction from raw clinical notes a relevant problem. In this paper, we propose an approach based on vector space and topic modeling, to structure the raw clinical data by capturing the semantic information in the nursing notes. Fuzzy similarity based data cleansing approach was used to merge anomalous and redundant patient data. Furthermore, we utilize eight supervised multi-label classification models to facilitate disease (ICD-9 code group) prediction. We present an exhaustive comparative study to evaluate the performance of the proposed approaches using standard evaluation metrics. Experimental validation on MIMIC-III, an open database, underscored the superior performance of the proposed Term weighting of unstructured notes AGgregated using fuzzy Similarity (TAGS) model, which consistently outperformed the state-of-the-art structured data based approach by 7.79% in AUPRC and 1.24% in AUROC. © 2019 Elsevier B.V.Item An effective feature extraction with deep neural network architecture for protein-secondary-structure prediction(Springer, 2021) Jayasimha, A.; Mudambi, R.; Pavan, P.; Lokaksha, B.M.; Bankapur, S.; Patil, N.With the increased importance of proteins in day-to-day life, it is imperative to know the protein functions. Deciphering protein structure elucidates protein functions. Experimental approaches for protein-structure analysis are expensive and time-consuming, and require high dexterity. Thus, finding a viable computational approach is vital. Due to the high complexity of predicting protein structure (tertiary structure) directly, research in this field aims at the protein-secondary-structure prediction which is directly related to its tertiary structure. This research aims at exploring a plethora of features, namely position-specific scoring matrices, hidden Markov model alignment matrices, and physicochemical properties, that carry rich information required to predict the secondary structure. Furthermore, it aims at exploring a suitable combination of the features which could capture diverse information about the protein secondary structure. Finally, a cascaded convolutional neural network and bidirectional long short-term memory architecture is fit on the models, and two evaluation metrics, namely, Q8 score and segment overlap score, are benchmarked on various datasets. Our proposed model trained on data of CB6133 dataset and tested on CB513 dataset beats the benchmark models by a minimum of 2.9%. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.Item Nature-inspired query optimisation models for medical information retrieval with relevance feedback(Inderscience Publishers, 2023) Jayasimha, A.; Mudambi, R.; Kamath S․, S.S.Medical information retrieval (MedIR) involves retrieving relevant medical-related information from a set of medical documents for a particular user query. As the volume of medical records grows, the challenging problem is determining those documents which best suiting a given query by considering user satisfaction. Statistical term weighting and probabilistic approaches for this purpose have several limitations. The gap between information need and user query can be addressed through query optimisation and relevance feedback. In this paper, we propose a document retrieval framework that incorporates query optimisation using techniques like genetic algorithm, particle swarm optimisation (PSO), and global swarm optimisation (GSO). Further, we use relevance feedback methods to reformulate the user query. The proposed techniques are applied to datasets with predefined relevance judgments to perform quantitative validation. Experimental results using the relevance judgements available in the University of Glasgow's Medline collection underscored the significant improvement achieved using BM25 scores as the fitness function. © 2023 Inderscience Enterprises Ltd.