Faculty Publications

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Author: search.filters.author.JagadeeshBabu, P.E.Subject: search.filters.subject.Doxorubicin

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    Synthesis of silica hollow core shell nanoparticles by sacrificial nitrated polystyrene template approach for targeted drug delivery application
    (Elsevier Ltd, 2021) Deepika, D.; JagadeeshBabu, P.E.
    Silica hollow core shell nanoparticles (SHCNs) were synthesized by employing nitrated polystyrene as sacrificial template. Polystyrene (PS) nanoparticles were functionalized with nitro functional group to modify the surface properties and to enhance the pore size of SHCNs. Calcination of silica coated nitrated PS nanoparticles lead to the formation of SHCNs and no traces of the polymer particles were found inside SHCNs as analyzed in fourier transform infrared radiation (FTIR). Transmission electron microscope (TEM) images were used to analyze the shell thickness of silica which was tuned between 15 and 35 nm. Specific surface area and average pore sizes of SHCNs were found to vary from 533.6 to 130.5 m2/g and 2.6 to 3.7 nm respectively. SHCNs were loaded with doxorubicin to evaluate the potential release kinetics by varying the silica shell thickness and pH of the release medium. SHCNs showed sustained release for 250 min at a pH of 7.4. © 2021 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the International Conference on Advances in Materials Research - 2019.
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    Role of graphene quantum dots synthesized through pyrolysis in the release behavior of temperature responsive poly (N,N-diethyl acrylamide) hydrogel loaded with doxorubicin
    (Taylor and Francis Inc. 325 Chestnut St, Suite 800 Philadelphia PA 19106, 2018) Havanur, S.; JagadeeshBabu, P.E.
    We have reported the synthesis and characterization of new drug carrier using Poly (N,N-diethyl acrylamide) (PDEA) and graphene quantum dots (GQDs). PDEA is a stimuli-responsive, macroporous polymer which has the ability to respond to change in surrounding temperature and addition of GQDs will help in improving the inherent characteristics of PDEA. In this research work, PDEA hydrogels along with GQDs have been synthesized by free radical polymerization. The effect of various concentrations of GQDs on the property of PDEA hydrogel was studied. The structural analysis of synthesized hydrogels was done using Fourier transform infrared spectroscopy (FT–IR). The internal surface morphology of porous hydrogels was observed using scanning electron microscope (SEM) micrographs. From the analysis, it has been observed that the equilibrium swelling ratio (ESR) and reswelling kinetics of the hydrogel significantly increased as the GQDs content was varied. The cancer drug (an anthracycline that is used for cancer chemotherapy) Doxorubicin (DOX) release behavior was studied and found that the performance of hydrogel is dependent on hydrogel composition, time, and surrounding temperature. The cytotoxicity of GQDs incorporated PDEA hydrogels gave a significant report which supports the potential application of hydrogel as an intelligent drug carrier. © 2018, © 2018 Taylor & Francis Group, LLC.
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    Synthesis and optimization of poly (N,N-diethylacrylamide) hydrogel and evaluation of its anticancer drug doxorubicin’s release behavior
    (Springer London, 2019) Havanur, S.; Farheenand, V.; JagadeeshBabu, P.E.
    A macroporous temperature-responsive poly(N,N-diethylacrylamide) (PDEA) hydrogel was synthesized and optimized through free radical polymerization. The optimized hydrogel was achieved by evaluating the swelling characteristics, physical stability and mechanical strength through altering the components namely concentration of N,N-diethylacrylamide (monomer), ammonium peroxodisulfate (initiator), N,N?-methylbisacrylamide (cross-linker) and N,N,N?,N?-tetramethylethylenediamine (accelerator). The equilibrium swelling behavior was performed gravimetrically, and the PDEA hydrogel synthesized at 36 °C exhibited a maximum swelling of 18.332 g.g ?1 . Also, the LCST of the prepared PDEA hydrogel was found to be around 29 °C. However, the results of time-controlled swelling and deswelling kinetics indicated that hydrogels are temperature sensitive. Further, characterization of the hydrogel was performed using scanning electron microscopy, differential scanning calorimetry, thermal gravimetric analysis, and Fourier transform infrared spectroscopy. The hydrogel was assessed for its cytotoxicity in MDA-MB-231 cell line by MTT assay. The release behavior of anticancer drug doxorubicin (DOX), a hydroxyl derivative of anthracycline, was studied at above and below the LCST temperature. It was found that the DOX release from the DOX-loaded hydrogels was significantly improved when the surrounding temperature of the release media was increased near to physiological temperature. The cumulative release profile of hydrogel at different temperatures was fitted to different kinetic model equations and non-Fickian diffusion release mechanism was revealed. These results suggest that PDEA has a potential application as an intelligent drug carrier. © 2018, Iran Polymer and Petrochemical Institute.