Faculty Publications

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Author: search.filters.author.JagadeeshBabu, J.B.Subject: search.filters.subject.Article

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    Synthesis and characterization of microporous hollow core-shell silica nanoparticles (HCSNs) of tunable thickness for controlled release of doxorubicin
    (Springer Netherlands rbk@louisiana.edu, 2018) Deepika, D.; JagadeeshBabu, J.B.
    Hollow core-shell silica nanoparticles (HCSNs) are being considered as one of the most favorable drug carriers to accomplish targeted drug delivery. In the present study, we developed a simple two-step method, employing polystyrene (PS) nanoparticles (150 ± 20 nm) as a sacrificial template for the synthesis of microporous HCSNs of size 230 ± 30 nm. PS core and the wall structure directing agent cetyl trimethyl ammonium bromide (CTAB) were removed by calcination. Monodispersed spherical HCSNs were synthesized by optimising the parameters like water/ethanol volume ratio, PS/tetraethyl orthosilicate (TEOS) weight ratio, concentration of ammonia, and CTAB. Transmission electron microscopy (TEM) revealed the formation of hollow core-shell structure of silica with tunable thickness from 15 to 30 nm while tailoring the concentration of silica precursor. The results obtained from the cumulative release studies of doxorubicin loaded microporous HCSNs demonstrated the dependence of shell thickness on the controlled drug release behavior. HCSNs with highest shell thickness of 30 nm and lowest surface area of 600 m2/g showed delay in the doxorubicin release, proving their application as a drug carrier in targeted drug delivery systems. The novel concept of application of microporous HCSNs of pore size ~ 1.3 nm with large specific surface area in the field of drug delivery is successful. © 2018, Springer Nature B.V.
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    Synthesis, Characterization and Performance Evaluation of TiO2-SnO2 photocatalyst for Removal of Toxic Hexavalent Chromium
    (Springer Science and Business Media Deutschland GmbH, 2022) Rathna, T.; JagadeeshBabu, J.B.; Ruben Sudhakar, D.R.
    Heavy metal pollution bears a substantial threat to flora, fauna, humans, and milieu. The elimination of hexavalent chromium [Cr(VI)] from polluted water is of considerable research interest from a health and environmental viewpoint. This work aims for photocatalytic reduction of Cr(VI) to Cr(III) using TiO2 and SnO2 as catalysts. The process parameters varied are catalyst dosage, pH, initial concentration of model pollutant with citric acid (CA) as a scavenger. TiO2-SnO2 (in the molar ratios 10:1, 20:1, 30:1, and 40:1)-based catalysts were synthesized using the hydrothermal method. The 40:1 catalyst showed higher photoactivity than other catalysts and could extend the optical activity in the visible light region. The complete reduction of Cr(VI) with a concentration of 15 mg/L and pH 3.0 was achieved when catalyst concentration was 0.6 g/L over a period of 30 min. The XRD (X-Ray Diffraction Spectroscopy) and ATR-FTIR (Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy) results confirm the Ti-Sn heterojunction formation, and XPS (X-ray Photoelectron Spectroscopy) analysis corroborate the presence of trivalent chromium [Cr(III)] on TiO2-SnO2 catalyst after reduction. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.