Faculty Publications

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Author: search.filters.author.JagadeeshBabu, J.Subject: search.filters.subject.polymer

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    Synthesis and characterization of silver decorated polysulfone/cellulose acetate hybrid ultrafiltration membranes using functionalized TiO2 nanoparticles
    (Desalination Publications dwt@deswater.com, 2017) Sri, K.S.; Nair, A.K.; JagadeeshBabu, J.
    Amine functionalized TiO2 nanoparticles were synthesized via surface reaction with 3-Aminopropyl triethoxysilane. These nanoparticles were added to polysulfone and cellulose acetate blend casting solutions in 1-Methyl-2-pyrrolidone to form hybrid membranes by phase inversion. The amine groups on the surface of the membranes were used as absorption sites for silver nanoparticles. The obtained membranes were characterized using Fourier Transform Infra Red spectroscopy, Scanning electron microscope and X-ray diffraction. Water uptake studies and contact angle measurements were done to evaluate hydrophilicity of the membranes. Pure water flux studies of the membrane were carried out in a dead end filtration unit. Rejection and antifouling studies were carried out using bovine serum albumin as a model protein. The hybrid membranes exhibited better permeability and fouling resistance. The hybrid membranes with silver decoration on the surface showed microbial resistance. © 2017 Desalination Publications. All rights reserved.
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    Fluorometric detection of bisphenol A using ?-cyclodextrin-functionalized ZnO QDs
    (Springer Science and Business Media Deutschland GmbH, 2021) Kadam, V.V.; Mohan Balakrishnan, R.M.; JagadeeshBabu, J.
    The estrogenic property of bisphenol A (BPA) leads to potential adverse health and ecological effects. A simple, selective, and cost-effective sensor capable of detecting BPA would have a noteworthy relevance for the environmental system. The present work illustrates the synthesis and characterization of ?-cyclodextrin (?-CD) functionalized zinc oxide (ZnO) quantum dots (QDs) for the selective detection of BPA. BPA has a fluorescence quenching effect on functionalized ZnO QDs, and the decrease in fluorescence intensity is associated with the BPA concentration between 2 and 10 ?M. Under the optimum reaction condition, a good linear correlation was obtained between relative fluorescence-quenching intensity of ?-cyclodextrin-functionalized ZnO QDs and BPA concentration (R2 = 0.9891). The lower detection limit of functionalized QDs for BPA was estimated to be 0.19 ?M, which is lower than the toxic limits in aquatic biota. The fluorescence-based detection of BPA may be ascribed to the electron transfer mechanism, which is elucidated with scientific details from the literature. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
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    Amidated pectin and gum Arabic aldehyde-based pH-sensitive hydrogel for targeted colonic treatment
    (Elsevier B.V., 2025) Singh, H.; JagadeeshBabu, J.; Mohan Balakrishnan, R.
    In this study, a novel pH-responsive hydrogel was developed by crosslinking amidated pectin(AmPec) with oxidised gum Arabic(GAA) by hydrogen and hemiacetal bonding without the need for toxic crosslinkers for oral delivery of doxorubicin to treat colon cancer. FTIR and NMR confirmed the amidation of pectin and oxidation of Gum Arabic. FTIR confirmed the formation of hydrogen and hemiacetal bonds in the hydrogel. X-ray diffraction(XRD) spectra showed the amorphous characteristic of AmPec-GAA hydrogels compared to their polymer precursors, confirming the formation of a crosslinked hydrogel. AmPec-GAA15 hydrogel swelled around 655 %±39.90 at pH 7.4 compared to 181 %±7.94 swelling at pH 1.2 after 72 h. The release of doxorubicin also followed the same trend, with only 4.48 % ±0.89 doxorubicin release at pH 1.2, while the drug release increased to 68.10 %±3.73 at pH 7.4 after 48 h. SEM micrographs revealed the macroporous and interconnected hydrogel structure with fewer pores in the hydrogel swelled in pH 1.2 compared with pH 7.4, where more visible pores were observed, indicating the pH-sensitive behaviour of the hydrogel. Hydrogel possessed excellent thermal and mechanical stability as revealed by TGA and rheology study, which can also be explored for tissue engineering applications. MTT assay on L929 cells showed cell viability above 95.1 %±,0.0074, demonstrating hydrogels' non-toxic and biocompatible behaviour. Meanwhile, Dox-loaded hydrogel induced higher cytotoxicity against HT-29 cells than free Dox in a dose-dependent manner. Therefore, the developed hydrogel can be used as an effective oral carrier to deliver doxorubicin to colon cancer while hindering its release in the stomach and thus preventing associated toxicity. © 2025 Elsevier B.V.