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Item In vivo anticancer and histopathology studies of Schiff bases on Ehrlich ascitic carcinoma cells. 1st Cancer Update.(2013) Dhanya, D.; Isloor, A.M.; Shetty, P.; Nayak, P.G.; Pai, K.S.R.Three Schiff bases in two different concentrations were evaluated for their anti-tumor activity against Ehrlich ascites carcinoma (EAC) bearing Swiss albino mice. The in vivo anti-tumor potency of Schiff bases was assessed by measuring the increase in mean survival time of the drug treated over untreated control mice and treated standard (cisplatin) mice. Their toxicity was assessed in vivo in normal, standard, and EAC-bearing mice by measuring the drug-induced changes in biochemical as well as hematological parameters. The histopathology studies to assess the toxicity of these compounds on vital organs also have been studied. Among the three Schiff bases studied, 4-({[3-(4-fluorophenyl)-1. H-pyrazol-4-yl]methylene}amino)-5-[(2-methylphenoxy)methyl]-1,2,4-triazole-3-thiol (SB-3) at an optimal dose of 100. mg/kg body weight was found to enhance the mean survival time of infected mice. Deviated hematological parameters and mean survival time in tumor bearing mice were found to be significantly restored towards normal after treatment with SB-3 100. mg/kg body weight of mice. The ALP and SGOT values were found to approach the normal range. A:G ratios also did not deviate from normal on treatment with SB-3. The histopathology studies revealed only mild hepatotoxicity and nephrotoxicity when compared to the normal and standard. The splenic cellularity also did not show much variation from normal. SB-3 at a prime dose of 100. mg has shown promising anticancer activity in vivo against EAC when compared to standard drug with minimum toxic effects. © 2010 .Item Synthesis and antimicrobial activities of some novel 1,2,4-triazole derivatives(2013) Mange, Y.J.; Isloor, A.M.; Malladi, S.; Isloor, S.; Fun, H.-K.In the present investigation, a series of new Schiff bases 4a-f were synthesized by the condensation of N-[(4-amino-5-sulfanyl-4. H-1,2,4-triazol-3-yl)methyl]-4-substituted-benzamides 3a-b with various substituted aromatic aldehydes in ethanol-dioxane mixture using catalytic amount of sulfuric acid. The starting materials 3a-b were in turn synthesized by the fusion of benzoyl glycine/substituted benzoylglycine with thiocarbohydrazide. Newly synthesized compounds were characterized by IR, NMR, mass spectra and elemental analyses. All the compounds were evaluated for their antibacterial and antifungal activity using the Minimum Inhibition Concentration (MIC) method by serial dilution technique. Few of the compounds were found to be biologically active. © 2011.Item Synthesis, characterization and antibacterial activity of some new pyrazole based Schiff bases(2013) Malladi, S.; Isloor, A.M.; Isloor, S.; Akhila, D.S.; Fun, H.-K.In the present study a series of new Schiff bases were synthesized. All the synthesized compounds were characterized by IR, 1H NMR, mass spectral and elemental analyses. Newly synthesized compounds were screened for their antibacterial (Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa) activity. The results revealed that, compounds 3f and 3c have exhibited significant biological activity against the tested microorganisms. © 2011.