Faculty Publications

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Publications by NITK Faculty

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Author: search.filters.author.Isloor, A.M.Subject: search.filters.subject.Bioactivity

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    Synthesis, characterization and antibacterial activity of some new pyrazole based Schiff bases
    (2013) Malladi, S.; Isloor, A.M.; Isloor, S.; Akhila, D.S.; Fun, H.-K.
    In the present study a series of new Schiff bases were synthesized. All the synthesized compounds were characterized by IR, 1H NMR, mass spectral and elemental analyses. Newly synthesized compounds were screened for their antibacterial (Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa) activity. The results revealed that, compounds 3f and 3c have exhibited significant biological activity against the tested microorganisms. © 2011.
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    Synthesis and in vitro biological evaluation of new pyrazole chalcones and heterocyclic diamides as potential anticancer agents
    (Elsevier B.V., 2015) Sankappa Rai, U.; Isloor, A.M.; Shetty, P.; Pai, K.S.R.; Fun, H.-K.
    Synthesis and characterization of new heterocyclic pyrazole chalcones (4a-. e) and diamide (6a-. e) derivatives are described. Pyrazole chalcones were synthesized by the reaction of pyrazole aldehydes and suitable aromatic ketones. Diamides were synthesized by the reaction of phthalic acid and amines. Newly synthesized compounds were characterized by spectral studies and their biological activity was assessed in vitro using MCF-7 (human breast adenocarcinoma) and HeLa (human cervical tumor cells) cell lines. Few of the synthesized molecules inhibited the growth of the human breast cancer cell lines and human cervical tumor cell lines at low micromolar to nanomolar concentrations. © 2014 King Saud University.