Faculty Publications
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Item Julolidine-hydrazide-based D-?-A fluorescent chemoprobes for detection of Al3+ and Differentiation of Arsenic species: Applications in portable test strips, ecological assessment, and DFT studies(Elsevier Inc., 2024) Hebbar, S.D.; K A, S.; Raval, K.; Trivedi, D.R.In this study, a novel donor-?-acceptor (D-?-A) chemoprobe was synthesized using julolidine and hydrazide derivatives. The probes S1R1 and S1R2 demonstrated promising capabilities in sensing Al3+ and AsO2- ions through fluorescence. Specifically, probes S1R1 and S1R2 exhibited selectivity towards detecting Al3+ ions, with detection limits of 0.0485 ppm and 0.1754 ppm, respectively. These probes were effectively applied in environmental monitoring for detecting Al3+ ions in various samples, including natural water, soil, pharmaceutical tablets, and E.coli cells, and also a portable test strip for the easy detection of Al3+ ions. Moreover, probe S1R2 showed discriminative detection of AsO2- over AsO43- ions in semi-aqueous media, with a detection limit of 0.1055 ppm. This discrimination ability is attributed to the lower hydration energy of AsO2- ions compared to AsO43- ions, enabling preferential binding to S1R2. The observed turn-on fluorescence performance of probes S1R1 and S1R2 upon the addition of Al3+ ions are attributed to the chelation-enhanced fluorescence (CHEF) phenomenon. Additionally, live cell imaging experiments demonstrated that probes S1R1 and S1R2 can effectively detect Al3+ ions within E.coli cells using a Cell imaging reader. © 2024 Elsevier B.V.Item Heterocyclic-based optical responsive chemosensors for the detection of arsenite and phosphate in semi-aqueous medium: Application in logic gate operations, RGB tool, and DFT studies(Elsevier B.V., 2025) Hebbar, S.D.; Trivedi, D.R.Highly selective and sensitive organic chemosensors S2R1-S2R3 were synthesized using thienyl-substituted pyridine derivative and characterized by various spectroscopic techniques. The effect of substituents on selectivity is observed in the chemosensors S2R1 through S2R3, with the rate of reactivity toward ions following the trend as -NO2 > -CN > –OCH3 group. The chemosensor S2R1 exhibited selectivity towards arsenite and phosphate, achieving a Limit of Detection (LOD) of 0.2672 ppm and 0.5042 ppm, respectively, in 30% aq. (CH3)2SO solution. It was also observed that S2R2 was selective for PO43? ions in 100% (CH3)2SO solution with an LOD of 0.521 ppm. The spectral redshifts observed in the organo-aqueous media potentializes the sensor to be colorimetrically active. The probe S2R1 showed the lowest LOD and high binding constant with AsO2? and PO43? ions. Other characterization techniques, such as electrochemical studies, 1H NMR titration, UV–visible titration, and DFT experiments, demonstrated the sensing mechanism of arsenite and phosphate ions with the chemosensors through an intermolecular hydrogen bonding and intermolecular charge transfer (ICT) process followed by its practical applicability for real world-sensing. © 2024 Elsevier B.V.