Faculty Publications

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Author: search.filters.author.Doddamani, D.Subject: search.filters.subject.Nanoparticles

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    Sacrificial sulphonated polystyrene template-assisted synthesis of mesoporous hollow core-shell silica nanoparticles for drug-delivery application
    (Springer, 2020) Doddamani, D.; JagadeeshBabu, J.
    Spherical mesoporous hollow core-shell silica nanoparticles (HCSNs) of size 200 ± 50 nm with tunable thickness from 20 to 60 nm are synthesized using a sacrificial sulphonated polystyrene (PS, particle size 160 nm) template. A facile method is adopted for the sulphonation of PS using sulphuric acid, which enhanced the negative charge on the surface of PS as confirmed by zeta potential analysis and Fourier transform infrared radiation analysis. The thickness of the silica shell is tuned by altering the concentration of the silica precursor and is found to increase due to the use of the sulphonated PS template. N2 adsorption/desorption studies reported the variation of specific surface area of HCSNs from 644.1 to 197.8 m2 g?1 and average pore size from 1.55 to 3.4 nm. The drug release behaviour of HCSNs with different shell thicknesses is investigated using doxorubicin as the model drug. A delay in the drug release for ~300 min is successfully achieved by employing HCSNs with enhanced thickness of 60 nm. Application of HCSNs in targeted drug delivery was further supported by the in-vitro cytotoxicity studies carried out on lung adenocarcinoma cells. © 2020, Indian Academy of Sciences.
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    Indentation fracture toughness of Aluminium-Graphite composites: influence of nano-particles
    (Gruppo Italiano Frattura, 2025) Ibrahim, A.; Niyaz Ahamed, M.B.; Ashoka, E.; Rajesh, A.M.; Bharath, P.B.; Doddamani, D.
    In the field of composite materials, extensive research has been undertaken on aluminum-graphite composites. However, a research gap has been identified regarding the specific influence of nano-sized graphite particles on their fracture toughness. Previous studies have predominantly focused on larger graphite particles or different reinforcement materials, resulting in relatively unexplored effects of nano-graphite particles. This research is deemed critical as it has the potential to generate lightweight, high-strength materials, aligning with the demands of aerospace, automotive, and structural engineering. The primary objective of this study is to investigate how the inclusion of nano-sized graphite particles affects the fracture toughness of aluminum-graphite composites. To achieve this objective, systematic dispersion and incorporation of nano-sized graphite particles into an aluminum matrix will be carried out. Mechanical testing, including fracture toughness assessments, will be conducted to evaluate the performance of the composite materials. Factors such as particle size, distribution, volume fraction, and interfacial bonding will also be characterized within the study. It is anticipated that the presence of nano-sized graphite particles will lead to a significant enhancement of the fracture toughness of the aluminum-graphite nanocomposites. This enhancement is expected to be attributed to crack deflection, tortuosity, altered stress distribution, and increased plastic deformation around cracks. © 2024.