Faculty Publications

Now showing 1 - 3 of 3

In vivo anticancer and histopathology studies of Schiff bases on Ehrlich ascitic carcinoma cells. 1st Cancer Update.
(2013) Dhanya, D.; Isloor, A.M.; Shetty, P.; Nayak, P.G.; Pai, K.S.R.
Three Schiff bases in two different concentrations were evaluated for their anti-tumor activity against Ehrlich ascites carcinoma (EAC) bearing Swiss albino mice. The in vivo anti-tumor potency of Schiff bases was assessed by measuring the increase in mean survival time of the drug treated over untreated control mice and treated standard (cisplatin) mice. Their toxicity was assessed in vivo in normal, standard, and EAC-bearing mice by measuring the drug-induced changes in biochemical as well as hematological parameters. The histopathology studies to assess the toxicity of these compounds on vital organs also have been studied. Among the three Schiff bases studied, 4-({[3-(4-fluorophenyl)-1. H-pyrazol-4-yl]methylene}amino)-5-[(2-methylphenoxy)methyl]-1,2,4-triazole-3-thiol (SB-3) at an optimal dose of 100. mg/kg body weight was found to enhance the mean survival time of infected mice. Deviated hematological parameters and mean survival time in tumor bearing mice were found to be significantly restored towards normal after treatment with SB-3 100. mg/kg body weight of mice. The ALP and SGOT values were found to approach the normal range. A:G ratios also did not deviate from normal on treatment with SB-3. The histopathology studies revealed only mild hepatotoxicity and nephrotoxicity when compared to the normal and standard. The splenic cellularity also did not show much variation from normal. SB-3 at a prime dose of 100. mg has shown promising anticancer activity in vivo against EAC when compared to standard drug with minimum toxic effects. © 2010 .
Boronic Acid-Based n-Type Semiconductor for Electronic Device Application
(Springer, 2022) Kagatikar, S.; Dhanya, D.; Kekuda, D.; Satyanarayana, M.N.; Kulkarni, S.D.; Karkera, C.
Electron transporting, or n-type, semiconductors can serve as charge-transport materials, and are ideal for use in organic electronic devices. Boron-based small organic molecules have garnered immense research attention as the heteroatom can effectively alter the electronic structures leading to excellent photophysical and electrochemical properties. A luminescent Schiff base (E)-(4-((2-(2-hydroxybenzoyl)hydrazono)methyl)phenyl)boronic acid (SHB) was prepared by a one-pot condensation reaction between salicyloyl hydrazide and formylphenylboronic acid. The synthesized molecule was chemically characterized by infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectrometry. The blue-emitting boronic acid-derived molecule displayed intramolecular charge transfer, high carrier concentration, good thermal stability, a reversible reduction tendency and formation of uniform amorphous thin films. A diode was successfully fabricated via a solution processing technique with an ideality factor of 7.76. Further, AC conductivity, dielectric constant, dielectric loss, and capacitance values in a frequency range of 10–1000 Hz were extracted from dielectric studies. The dielectric constant of SHB was found to be 9.71 with an AC conductivity of 6.34 × 10−9 Ω−1 cm−1 at 1000 Hz. Graphical Abstract: [Figure not available: see fulltext.] © 2022, The Author(s).
Fluorene-vanillin hybrid: A multifunctional fluorophore for latent fingerprint detection and sustainable offset security ink development
(Elsevier B.V., 2025) K Jain, R.; P.j, A.; Dhanya, D.; Bhagavath, P.; Vatti, A.K.; Mahadeva Prasad, M.P.; K, U.B.; Alex, A.
Fluorophores play a pivotal role in forensic science and anticounterfeit applications due to their unique and distinct emission features, which enable visualization and authentication. In the pursuit for advanced fluorescent pigments, ortho vanillin-fluorene Schiff base (OAF) with bright orange fluorescence was synthesized using a cost-effective, simple, and one-step method. This fluorophore was highly effective in developing latent fingerprints (LFPs), enabling visualization of level 1–3 features on nonporous glass and semi-porous leather under 365 nm UV light. The interaction between glycine in the fingerprint residue on glass substrate and OAF was analyzed through computational studies and further validated using ATR-FTIR analysis. The FESEM images of the latent prints revealed detailed surface morphology and particle distribution on the ridges of the fingermarks. Further, fluorescent images of LFPs were successfully developed on sticky paint, moist glass, multicolored compact disc, and uneven leaf surface, demonstrating the material's versatility on challenging substrates. Moreover, the powder dusting of composite powder of OAF and JUP-AS120, a commercially available pigment enabled enhanced LFP visualization on glass under both 365 and 980 nm light sources for better contrast and minimal background fluorescence, while minimising degradation of fingerprint residues over time. In addition, an OAF spray was formulated using nitrocellulose resin, ethyl acetate and carbitol for broader forensic application, which facilitated LFP visualization down to fine minutiae details on porous, semi-porous and non-porous substrates. Furthermore, to address the growing rates of counterfeited products/banknotes/security documents, an ecofriendly composite security ink was formulated using OAF and JUP-AS120 to obtain offset prints with excellent resistance to photobleaching and scuffing on paper substrate. The ink film exhibited multilevel authentication features: orange fluorescence under a 365 nm light source, and green and red emissions without and with a 610 nm band pass filter, respectively under 980 nm laser source, enhancing security and making forgery more challenging. Additionally, biocompatible OAF can be incorporated in ink pads to offer a dual layer of validation for fingerprints on security documents: optical authentication by leveraging the ink's fluorescence properties and biometric recognition through fingerprint patterns. © 2025 The Author(s)

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