Faculty Publications
Permanent URI for this communityhttps://idr.nitk.ac.in/handle/123456789/18736
Publications by NITK Faculty
Browse
2 results
Search Results
Item Designing of A Synergistic Mixture of Natural Antioxidants Through Statistical Approaches for Enhancing the Oxidative Stability of Sardine Oil(Enviro Research Publishers, 2023) Mishra, S.K.; Belur, P.D.; Chandrasekar, V.; Iyyaswami, R.Given the diverse routes of oxidation and a variety of oxidation products, the right combination of antioxidants is expected to exhibit synergistic effects in retarding refined sardine oil oxidation. In this study, a full factorial design (24) was utilized to choose a combination of natural antioxidants which exhibit interactive effect and response surface modelling (RSM) was used to identify the optimal concentration of the selected antioxidant mixture which exhibit synergistic effect. Catechin and resveratrol showed a strong interactive effect among the four natural antioxidants (sinapic acid, vanillic acid, catechin, and resveratrol) studied in sardine oil stored for 50 days at 25ºC under darkness. Two optimal concentrations of interactive antioxidants were found through RSM. Catechin and resveratrol at 0.5 mM and 0.625 mM respectively, exhibited a strong synergistic effect whereas, at 0.5 mM and 3.7 mM respectively, showed prooxidant effect. This is the first of its kind report on the formulation of a synergistic antioxidant mixture for retarding oxidation using statistical approaches. © 2023 The Author(s).Item Synthesis and characterization of 3,4-dihydroxyphenyl acetic acid esters and study of their efficacy in bulk fish oil(Elsevier Ltd, 2024) Arunachalam, S.S.; Chandrasekar, V.; Belur, P.D.Lipophilization of natural antioxidants is a proven strategy to enhance the solubility in bulk oil systems, thereby increasing their efficacy against oxidative degradation. This study aims to synthesize esters of 3,4-dihydroxyphenylacetic acid (3,4-DHPA) using Amberlyst-15 and to study the application of these esters in refined fish oil. Lipophilic esters were synthesized by esterification and transesterification of 3,4-DHPA in various solvent systems. Esters of methanol, butanol and hexanol were obtained with percent conversion of 81.1, 69.3 and 78.8 respectively, and were subjected to molecular characterization and in vitro oxidant assays. The 3,4-DHPA and its methyl ester showed 36% reduction in the TOTOX value over 30 days of storage. The length of the acyl chain in the ester was found to exert a high influence on its efficacy and lipophilicity. This is the first report of 3,4-DHPA and its lipophilic esters studied for enhancing the oxidative stability of fish oil. © 2024 Elsevier Ltd