Faculty Publications
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Item Efficient and robust deep learning architecture for segmentation of kidney and breast histopathology images(Elsevier Ltd, 2021) Chanchal, A.K.; Kumar, A.; Lal, S.; Kini, J.Image segmentation is consistently an important task for computer vision and the analysis of medical images. The analysis and diagnosis of histopathology images by using efficient algorithms that separate hematoxylin and eosin-stained nuclei was the purpose of our proposed method. In this paper, we propose a deep learning model that automatically segments the complex nuclei present in histology images by implementing an effective encoder–decoder architecture with a separable convolution pyramid pooling network (SCPP-Net). The SCPP unit focuses on two aspects: first, it increases the receptive field by varying four different dilation rates, keeping the kernel size fixed, and second, it reduces the trainable parameter by using depth-wise separable convolution. Our deep learning model experimented with three publicly available histopathology image datasets. The proposed SCPP-Net provides better experimental segmentation results compared to other existing deep learning models and is evaluated in terms of F1-score and aggregated Jaccard index. © 2021 Elsevier LtdItem Deep structured residual encoder-decoder network with a novel loss function for nuclei segmentation of kidney and breast histopathology images(Springer, 2022) Chanchal, A.K.; Lal, S.; Kini, J.To improve the process of diagnosis and treatment of cancer disease, automatic segmentation of haematoxylin and eosin (H & E) stained cell nuclei from histopathology images is the first step in digital pathology. The proposed deep structured residual encoder-decoder network (DSREDN) focuses on two aspects: first, it effectively utilized residual connections throughout the network and provides a wide and deep encoder-decoder path, which results to capture relevant context and more localized features. Second, vanished boundary of detected nuclei is addressed by proposing an efficient loss function that better train our proposed model and reduces the false prediction which is undesirable especially in healthcare applications. The proposed architecture experimented on three different publicly available H&E stained histopathological datasets namely: (I) Kidney (RCC) (II) Triple Negative Breast Cancer (TNBC) (III) MoNuSeg-2018. We have considered F1-score, Aggregated Jaccard Index (AJI), the total number of parameters, and FLOPs (Floating point operations), which are mostly preferred performance measure metrics for comparison of nuclei segmentation. The evaluated score of nuclei segmentation indicated that the proposed architecture achieved a considerable margin over five state-of-the-art deep learning models on three different histopathology datasets. Visual segmentation results show that the proposed DSREDN model accurately segment the nuclear regions than those of the state-of-the-art methods. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Item FPGA implementation of deep learning architecture for kidney cancer detection from histopathological images(Springer, 2024) Lal, S.; Chanchal, A.K.; Kini, J.; Upadhyay, G.K.Kidney cancer is the most common type of cancer, and designing an automated system to accurately classify the cancer grade is of paramount importance for a better prognosis of the disease from histopathological kidney cancer images. Application of deep learning neural networks (DLNNs) for histopathological image classification is thriving and implementation of these networks on edge devices has been gaining the ground correspondingly due to high computational power and low latency requirements. This paper designs an automated system that classifies histopathological kidney cancer images. For experimentation, we have collected Kidney histopathological images of Non-cancerous, cancerous, and their respective grade of Renal Cell Carcinoma (RCC) from Kasturba Medical College (KMC), Mangalore, Karnataka, India. We have implemented and analyzed performances of deep learning architectures on a Field Programmable Gate Array (FPGA) board. Results yield that the Inception-V3 network provides better accuracy for kidney cancer detection as compared to other deep learning models on Kidney histopathological images. Further, the DenseNet-169 network provides better accuracy for kidney cancer grading as compared to other existing deep learning architecture on the FPGA board. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.Item Classification and grade prediction of kidney cancer histological images using deep learning(Springer, 2024) Chanchal, A.K.; N, S.; Lal, S.; Kumar, S.; Saxena, P.U.P.Renal Cell Carcinoma (RCC) is the most common malignant tumor (85%) of kidney cancer and has a complex histological pattern and nuclear structure. The manual diagnosis of kidney cancer or any other cancer from histopathology image depends on the knowledge and experience of pathologists, and the pathologist’s experience influences the results. According to studies, the kind of histology in kidney cancer is related to the prognosis and course of treatment. Since the kind of histology, molecular profile, and stage of the disease all affect how the disease is treated, there is an essential need to develop an automated system that can precisely analyze the histopathological images of the disease. This work demonstrates how a deep learning framework can be used to predict and classify associated grades of RCC from provided haematoxylin and eosin (H &E) images. The proposed model focuses on two important tasks- First to capture and extract associated features from the H &E images of five different grades. Second, to classify the new set of unseen H &E images into five separate grades using the obtained features. The proposed architecture has been tested and experimented on two independent datasets containing H &E stained histopathology images. The proposed architecture has been examined using the following performance metrics namely precision, recall, F1 - score, accuracy, Floating-point operations (FLOPs), and the total number of parameters. The obtained results show that the proposed architecture attains better results over seven state-of-the-art deep learning architectures on two different H &E stained histopathology image datasets. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.