Faculty Publications
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Item Synthesis of functionalized benzo[1,3]dioxin-4-ones from salicylic acid and acetylenic esters and their direct amidation(Royal Society of Chemistry, 2021) Bhaskaran, R.P.; Nayak, K.H.; Babu, B.P.Direct synthesis of 4H-benzo[d][1,3]dioxin-4-one derivatives from salicylic acids and acetylenic esters (both mono- and disubstituted) has been described. The reaction is mediated by CuI and NaHCO3in acetonitrile. Room temperature amidation of the synthesized 1,3-benzodioxinones with primary amines readily afforded the corresponding salicylamides in moderate to good yields. © The Royal Society of Chemistry 2021.Item Synthesis of 5-(pyrazol-4-yl) pentanoic acids and 4-(pyrazol-4-yl) butanoic acids via a cascade annulation/ring-opening reaction between hydrazone and dienone(Royal Society of Chemistry, 2025) Nayak, K.H.; Jijin, R.K.; Babu, B.P.Herein, we report an interesting [3 + 2] annulation/ring-opening cascade reaction between hydrazones and exocyclic dienones via an aerobic, copper(ii) catalysis to synthesize 5-(pyrazol-4-yl) pentanoic acid and 4-(pyrazol-4-yl) butanoic acid derivatives. The annulation first affords a spiro pyrazoline with unprecedented regiochemistry, followed by a cascade nucleophilic ring opening by water to yield pyrazolyl pentanoic and butanoic acid derivatives in good yield. Broad substrate scope, inexpensive and green catalyst and oxidant, and relatively mild reaction conditions enhance the versatility of this protocol. © 2025 The Royal Society of Chemistry.