Faculty Publications
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Item Recent advances and future potential of computer aided diagnosis of liver cancer on computed tomography images(2011) Arakeri, M.P.; Guddeti, G.Liver cancer has been known as one of the deadliest diseases. It has become a major health issue in the world over the past 30 years and its occurrence has increased in the recent years. Early detection is necessary to diagnose and cure liver cancer. Advances in medical imaging and image processing techniques have greatly enhanced interpretation of medical images. Computer aided diagnosis (CAD) systems based on these techniques play a vital role in the early detection of liver cancer and hence reduce death rate. The concept of computer aided diagnosis is to provide a computer output as a second opinion in analysis of liver cancer. It assists radiologist's image interpretation by improving accuracy and consistency of radiological diagnosis and also by reducing image analysis time. The main objective of this paper is to provide an overview of recent advances in the development of CAD systems for analysis of liver cancer. Medical imaging system based on computer tomography will be focused as it is particularly suitable for detecting liver tumors. The paper begins with introduction to liver tumors and medical imaging techniques. Then the key CAD techniques developed recently for liver tumor detection, classification, case-based reasoning based on image retrieval and 3D reconstruction are presented. This article also explores the future key directions and highlights the research challenges that need to be addressed in the development of CAD system which can help the radiologist in improving the diagnostic accuracy. © Springer-Verlag 2011.Item Computer-aided diagnosis system for tissue characterization of brain tumor on magnetic resonance images(Springer London, 2015) Arakeri, M.P.; Guddeti, G.R.M.The manual analysis of brain tumor on magnetic resonance (MR) images is time-consuming and subjective. Thus, to avoid human errors in brain tumor diagnosis, this paper presents an automatic and accurate computer-aided diagnosis (CAD) system based on ensemble classifier for the characterization of brain tumors on MR images as benign or malignant. Brain tumor tissue was automatically extracted from MR images by the proposed segmentation technique. A tumor is represented by extracting its texture, shape, and boundary features. The most significant features are selected by using information gain-based feature ranking and independent component analysis techniques. Next, these features are used to train the ensemble classifier consisting of support vector machine, artificial neural network, and k-nearest neighbor classifiers to characterize the tumor. Experiments were carried out on a dataset consisting of T1-weighted post-contrast and T2-weighted MR images of 550 patients. The developed CAD system was tested using the leave-one-out method. The experimental results showed that the proposed segmentation technique achieves good agreement with the gold standard and the ensemble classifier is highly effective in the diagnosis of brain tumor with an accuracy of 99.09 % (sensitivity 100 % and specificity 98.21 %). Thus, the proposed system can assist radiologists in an accurate diagnosis of brain tumors. © 2013, Springer-Verlag London.