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Author: search.filters.author.Annappa, B.Subject: search.filters.subject.Algorithms

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    Transcriptional processes: Models and inference
    (World Scientific Publishing Co. Pte Ltd wspc@wspc.com.sg, 2018) Shetty, K.S.; Annappa, B.
    Many biochemical events involve multistep reactions. One of the most important biological processes that involve multistep reaction is the transcriptional process. Models for multistep reaction necessarily need multiple states and it is a challenge to compute model parameters that best agree with experimental data. Therefore, the aim of this work is to design a multistep promoter model which accurately characterizes transcriptional bursting and is consistent with observed data. To address this issue, we develop a model for promoters with several OFF states and a single ON state using Erlang distribution. To explore the combined effects of model and data, we combine Monte Carlo extension of Expectation Maximization (MCEM) and delay Stochastic Simulation Algorithm (DSSA) and call the resultant algorithm as delay Bursty MCEM. We apply this algorithm to time-series data of endogenous mouse glutaminase promoter to validate the model assumptions and infer the kinetic parameters. Our results show that with multiple OFF states, we are able to infer and produce a model which is more consistent with experimental data. Our results also show that delay Bursty MCEM inference is more efficient. © 2018 World Scientific Publishing Europe Ltd.
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    Influence maximization in large social networks: Heuristics, models and parameters
    (Elsevier B.V., 2018) Sumith, N.; Annappa, B.; Bhattacharya, S.
    Online social networks play a major role not only in socio psychological front, but also in the economic aspect. The way social network serves as a platform of information spread, has attracted a wide range of applications at its doorstep. In recent years, lot of efforts are directed to use the phenomenon of vast spread of information, via social networks, in various applications, ranging from poll analysis, product marketing, identifying influential users and so on. One such application that has gained research attention is the influence maximization problem. The influence maximization problem aims to fetch the top influential users in the social networks. The aim of the paper is to provide a comprehensive analysis on the state of art approaches towards identifying influential users. In this review, we discuss various challenges and approaches to identify influential users in online social networks. This review concludes with future research direction, helping researchers to bring possible improvements to the existing body of work. © 2018 Elsevier B.V.