Journal Articles
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Item Bio-corrosion impacts on mechanical integrity of ZM21 Mg for orthopaedic implant application processed by equal channel angular pressing(Springer, 2021) Sekar, P.; Nyahale, M.B.; Naik, G.M.; Narendranath, N.; Prabhu, A.; Rekha, P.D.The mechanical integrity of rolled ZM21 Mg was improved by equal channel angular pressing (ECAP) to function as a potential biodegradable bone screw implant. Electron backscattered diffraction (EBSD) revealed deformed grains of 45 µm observed in rolled ZM21 Mg. They were transformed to equiaxed fine grains of 5.4 µm after 4th pass ECAP. The yield strength of rolled and ECAPed ZM21 Mg alloys were comparable. In contrast, 4th pass ZM21 Mg exhibited relatively higher elongation when compared to rolled sample. The mechanical properties of rolled and ECAPed ZM21 Mg were dependant on both grain refinement and crystallographic texture. The rolled and 4th pass ECAPed tensile samples exhibited nonlinear deterioration of mechanical properties when tested after 7, 14, 21 and 28 days immersion in Hank’s solution. The evaluation signifies that regardless their processing condition, ZM21 Mg alloys are suitable for surgical areas that requires high mechanical strength. In addition, the 4th pass ECAP samples were viable to MG-63 cells proving themselves to be promising candidates for future in vivo studies. [Figure not available: see fulltext.] © 2021, The Author(s).Item ProsGradNet: An effective and structured CNN approach for prostate cancer grading from histopathology images(Elsevier Ltd, 2025) Prabhu, A.; Sravya, N.; Lal, S.; Kini, J.Prostate cancer (PCa) is one of the most prevalent and potentially fatal malignancies affecting men globally. The incidence of prostate cancer is expected to double by 2040, posing significant health challenges. This anticipated increase underscores the urgent need for early and precise diagnosis to facilitate effective treatment and management. Histopathological analysis using Gleason grading system plays a pivotal role in clinical decision making by classifying cancer subtypes based on their cellular characteristics. This paper proposes a novel deep CNN model named as Prostate Grading Network (ProsGradNet), for the automatic grading of PCa from histopathological images. Central to the approach is the novel Context Guided Shared Channel Residual (CGSCR) block, that introduces structured methods for channel splitting and clustering, by varying group sizes. By grouping channels into 2, 4, and 8, it prioritizes deeper layer features, enhancing local semantic content and abstract feature representation. This methodological advancement significantly boosts classification accuracy, achieving an impressive 92.88% on Prostate Gleason dataset, outperforming other CNN models. To demonstrate the generalizability of ProsGradNet over different datasets, experiments are performed on Kasturba Medical College (KMC) Kidney dataset as well. The results further confirm the superiority of the proposed ProsGradNet model, with a classification accuracy of 92.68% on the KMC Kidney dataset. This demonstrates the model's potential to be applied effectively across various histopathological datasets, making it a valuable tool to fight against cancer. © 2025 Elsevier LtdItem High-pressure torsion of biodegradable Mg?Zn?Mn alloy and investigate mechanical and corrosion behaviour(Nature Research, 2025) Kumar, P.; Anne, G.; Ramesh, S.; Kudva, S.A.; Ramesh, M.R.; Doddamani, M.; Prabhu, A.; Sahu, S.Considering their biodegradability in physiological environments and similar elastic modulus to natural bone, magnesium alloys have generated a lot of interest as biodegradable implant materials. Their poor corrosion resistance is primarily a result of the inhomogeneous distribution of their second phase, which limits their clinical application. High pressure torsion (HPT) one of the severe plastic deformation techniques which provides an opportunity to process materials with low formability such as magnesium at room temperature. The present study HPT is conducted for Mg-Zn-Mn alloy up to ten revolutions at room temperature. Optical, scanning, and transmission electron microscopes were used to examine the microstructures of base material (BM) and ten revolution HPT samples. Significant microhardness improvement was observed in HPT N10 samples (222 Hv) as compared to BM samples (68 Hv). It was determined that the improvement in microhardness was primarily due to dislocation strengthening, fine grain strengthening, and second phase strengthening. Potentiodynamic polarisation and electrochemical impedance spectroscopy (EIS) were used in a simulated body fluid (SBF) solution to assess the corrosion behaviour. When compared to the BM sample (0.0243 mm/y), the corrosion resistance of the HPT N10 sample (0.0012 mm/y) increased significantly. This was mostly due to the smaller grain size and uniform dispersion of the secondary phases, which result in a uniform corrosion. Further, obtained data from the cytotoxicity assay carried out using the MTT method indicated the compatibility of the Mg-Zn-Mn alloy on MG-63 osteoblast-like cells, further substantiating its safety on the bone cells. © The Author(s) 2025.