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Item ADConv-Net: Advanced Deep Convolution Neural Network for COVID-19 Diagnostics Using Chest X-Ray and CT Images(Springer, 2025) Kumar, S.; Bhowmik, B.The worldwide COVID-19 epidemic has emerged as a significant concern, affecting daily lives and underscoring the importance of early diagnosis for effective treatment in medical and healthcare settings. Current diagnostic testing for COVID-19 is sluggish, typically requiring hours to get results. Detection of COVID-19 from medical imaging presents a challenging task that has gained substantial interest from experts worldwide. Essential imaging modalities for diagnosing COVID-19 include chest X-rays and computed tomography (CT) scans. By contrast, most of the chest radiography can be completed in within fifteen minutes. Thus, employing chest radiography gives a possibility for early and reliable diagnosis of COVID-19, intending to relieve therapeutic obstacles for patients and speed up the diagnostic process. Recently, deep learning (DL) techniques have been shown to be effective in image-based diagnostics. This paper proposed an advanced deep convolution neural network (ADConv-Net) for COVID-19 detection and categorization using chest X-ray and CT images. The proposed technique is not only capable of recognizing critical connections and similarities in image classification, but also leads to improved diagnostic accuracy. The proposed model undergoes thorough evaluation for standard performance metrics. After evaluation, the ADConv-Net model achieves high accuracies of 98.84% and 97.25% in training and testing for X-ray images and 99.41% and 98.87% in training and testing for CT images, respectively. Additionally, the proposed model demonstrates strong performance, with AUC values of 0.993 and 0.996 for X-ray and CT images, respectively. Further, the model also introduces a heatmap approach for displaying COVID-19 disease areas. Subsequently, radiologists can find COVID-19 disorders in chest X-ray and CT images with this approach. © The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd. 2025.Item EffiCOVID-net: A highly efficient convolutional neural network for COVID-19 diagnosis using chest X-ray imaging(Academic Press Inc., 2025) Kumar, S.; Bhowmik, B.The global COVID-19 pandemic has drastically affected daily life, emphasizing the urgent need for early and accurate detection to provide adequate medical treatment, especially with limited antiviral options. Chest X-ray imaging has proven crucial for distinguishing COVID-19 from other respiratory conditions, providing an essential diagnostic tool. Deep learning (DL)-based models have proven highly effective in image diagnostics in recent years. Many of these models are computationally intensive and prone to overfitting, especially when trained on limited datasets. Additionally, conventional models often fail to capture multi-scale features, reducing diagnostic accuracy. This paper proposed a highly efficient convolutional neural network (CNN) called EffiCOVID-Net, incorporating diverse feature learning units. The proposed model consists of a bunch of EffiCOVID blocks that incorporate several layers of convolution containing (3×3) filters and recurrent connections to extract complex features while preserving spatial integrity. The performance of EffiCOVID-Net is rigorously evaluated using standard performance metrics on two publicly available COVID-19 chest X-ray datasets. Experimental results demonstrate that EffiCOVID-Net outperforms existing models, achieving 98.68% accuracy on the COVID-19 radiography dataset (D1), 98.55% on the curated chest X-ray dataset (D2), and 98.87% on the mixed dataset (DMix) in multi-class classification (COVID-19 vs. Normal vs. Pneumonia). For binary classification (COVID-19 vs. Normal), the model attains 99.06%, 99.78%, and 99.07% accuracy, respectively. Integrating Grad-CAM-based visualizations further enhances interpretability by highlighting critical regions influencing model predictions. EffiCOVID-Net's lightweight architecture ensures low computational overhead, making it suitable for deployment in resource-constrained clinical settings. A comparative analysis with existing methods highlights its superior accuracy, efficiency, and robustness performance. However, while the model enhances diagnostic workflows, it is best utilized as an assistive tool rather than a standalone diagnostic method. © 2025 Elsevier Inc.Item Machine Learning Framework for Classification of COVID-19 Variants Using K-mer Based DNA Sequencing(John Wiley and Sons Inc, 2025) Kumar, S.; Raju, S.; Bhowmik, B.Accurate classification of viral DNA sequences is essential for tracking mutations, understanding viral evolution, and enabling timely public health responses. Traditional alignment-based methods are often computationally intensive and less effective for highly mutating viruses. This article presents a machine learning framework for classifying DNA sequences of COVID-19 variants using K-mer-based tokenization and vectorization techniques inspired by Natural Language Processing (NLP). DNA sequences corresponding to Alpha, Beta, Gamma, and Omicron variants are obtained from the Global Initiative on Sharing All Influenza Data (GISAID) database and encoded into feature vectors. Multiple classifiers, including Extra Trees, Random Forest, Support Vector Classifier (SVC), Decision Tree, Logistic Regression, Naive Bayes, K-Nearest Neighbor (KNN), Ridge Classifier, Stochastic Gradient Descent (SGD), and XGBoost, are evaluated based on accuracy, precision, recall, and F1-score. The Extra Trees model achieved the highest accuracy of 93.10% (Formula presented.) 0.42, followed by Random Forest with 92.60% (Formula presented.) 0.38, both demonstrating robust and balanced performance. Statistical significance tests confirmed the robustness of the results. The results validate the effectiveness of K-mer-based encoding combined with traditional machine learning models in classifying COVID-19 variants, offering a scalable and efficient solution for genomic surveillance. © 2025 Wiley Periodicals LLC.