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Item Stimuli-responsive and cellular targeted nanoplatforms for multimodal therapy of skin cancer(Elsevier B.V., 2021) Padya, B.S.; Pandey, A.; Pisay, M.; Koteshwara, K.B.; Raghu Chandrashekar, R.; Bhat, K.U.; Biswas, S.; Mutalik, S.Interdisciplinary applications of nanopharmaceutical sciences have tremendous potential for enhancing pharmacokinetics, efficacy and safety of cancer therapy. The limitations of conventional therapeutic platforms used for skin cancer therapy have been largely overcome by the use of nanoplatforms. This review discusses various nanotechnological approaches experimented for the treatment of skin cancer. The review describes various polymeric, lipidic and inorganic nanoplatforms for efficient therapy of skin cancer. The stimuli-responsive nanoplatforms such as pH-responsive as well as temperature-responsive platforms have also been reviewed. Different strategies for potentiating the nanoparticles application for cancer therapy such as surface engineering, conjugation with drugs, stimulus-responsive and multimodal effect have also been discussed and compared with the available conventional treatments. Although, nanopharmaceuticals face challenges such as toxicity, cost and scale-up, efforts put-in to improve these drawbacks with continuous research would deliver exciting and promising results in coming days. © 2020 Elsevier B.V.Item Optimization of Annealing Parameters for Ferritic Hot-Rolled IF Grade Steel(Springer, 2022) Kumar, D.S.; Sambandam, S.; Bhat, K.U.Ferritic hot rolling of low carbon steel is now widely adopted by steelmakers for reducing energy costs and increasing the yield. These ferritic hot-rolled coils carry forward different grain morphology and texture which result in variation in properties after cold rolling and annealing compared to austenitic hot-rolled coils. These ferritic hot-rolled coils require different annealing treatments based on the hot rolling temperature for better results. In the present work, a Nb–Ti stabilized interstitial free (IF) grade steel was hot rolled at two different temperatures in the ferritic regime in an industrial hot strip mill and was subsequently cold rolled. These cold-rolled sheets were subjected to different continuous annealing cycles with soaking temperatures varying from 740 to 820 °C on a thermo-mechanical simulator for optimization of temperatures and study its effect on microstructure and properties. These coils were compared with simulated conventional austenitic hot-rolled coils. Ferritic rolled coils show better elongation and a higher percentage of equiaxed grains indicating better formability. The optimum continuous annealing temperature was found to be a function of hot rolling temperature in the ferritic regime. Elongation and grain size increased with an increase in temperature in all the samples, but the ferritic rolled coils show faster change due to higher stored energy. Comparison of elongation and microstructure indicates that temperatures above 780 °C should be sufficient for achieving complete recrystallization in ferritic rolled samples, compared to 810 °C required in the conventional austenitic rolled sheets which is an industrial advantage. Based on simulation studies, full-scale plant continuous annealing was carried out under the optimized temperature conditions where microstructure and properties matched closely with the simulation results and electron backscatter diffraction (EBSD) analysis confirmed improved texture. © 2022, ASM International.Item SiC particulate reinforced A356 Al metal matrix composites were laser treated using pulsed Nd-YAG laser beam. The processing was carried out in air atmosphere at varying pulse energy (5 to 20 J) and scan rates (30 to 150 mm/sec). The samples were cut perpendicular to the track and they were characterized using optical microscopy, scanning electron microscopy and X-ray diffraction. Microstructure of laser treated region consists of regular succession of coarse and fine microstructure signifying the presence of low velocity bands. Transition from cellular/columnar dendritic to equiaxed dendritic structure has been observed. Microstructure of samples laser treated with specific energy greater than 13 kJ/cm2 show presence of Al 4C3 platelets. © 2004 Kluwer Academic Publishers.(Microstructural studies in low specific energy laser surface treated Al(A356)-SiCp composites) Bhat, K.U.; Surappa, M.K.2004Item Formation of composite surface during friction surfacing of steel with aluminium(2012) Janakiraman, S.; Bhat, K.U.Commercial pure aluminium was deposited on medium carbon steel using friction surfacing route. An aluminium rod was used as the consumable tool. Normal load and tool rotation speed were the variables. Under certain combinations of load and speed the deposition was continuous and uniform. The deposit consisted of Al embedded with fine particles of iron. The interface between substrate material and deposited material was smooth and relatively small. A mechanism is discussed for formation of a composite surface on the steel substrate. © 2012 S. Janakiraman and K. Udaya Bhat.Item Influence of nano-aluminum-hydroxide on tribological, mechanical and flammability properties of E-glass fabric/epoxy multi-layered laminates(Huthig GmbH, 2014) Shivamurty, B.; George, G.; Bhat, K.U.; Anandhan, S.E-glass fabric/nano aluminum hydroxide (ATH)/epoxy composites were prepared by manual lay-up and compression molding. An image processing tool was used to quantify fineness of dispersion of nano-ATH particles in epoxy. Fourier transform infrared (FTIR) spectroscopy was used to understand the interaction between nano-ATH and epoxy. Mechanical properties, sliding wear resistance and fire retardance of these composites improved upon addition of nano-ATH. The composite containing 0.125 wt% of nano-ATH exhibited optimum mechanical properties and low specific wear rate.Item Hot corrosion behaviour of HVOF sprayed stellite-6 coatings on gas turbine alloys(2014) Jegadeeswaran, N.; Ramesh, M.R.; Sampath, S.; Bhat, K.U.The coal burned natural gas in contact with gas turbine can contain impurities of sodium, sulfur, vanadium, silicon and possibly lead and phosphorous, induce accelerated hot corrosion during long term operation. Coatings are frequently applied on gas turbine components in order to restrict surface degradation and to obtain accurate lifetime expectancies. High velocity oxy-fuel thermal spraying has been used to deposit Stellite-6 alloy coatings on turbine alloys. Hot corrosion behavior of the coatings were investigated for 50 cycles of 1 h heating at 800 C followed by 20 min cooling in presence of Na 2SO4 + 50 % V2O5 measuring weight gain (or loss). X-ray diffraction and SEM/EDAX techniques were used to characterize the oxide scale formed. The superior performance of Stellite-6 coating can be attributed to continuous and protective thin oxide scale of CoO, Cr2O3 and SiO2 formed on the surface. The coating region beneath this thin oxide scale was partially oxidized. Uncoated SuperCo-605 and MDN-121 showed less weight gain than Stellite-6 coated samples, but they showed spalling or sputtering during cyclic oxidation. Stellite-6 coating was dense and pore free even after 50 cycles, indicating that it can resist the hot corrosion cycle. © 2013 Indian Institute of Metals.Item Preparation and antifouling properties of PVDF ultrafiltration membranes with polyaniline (PANI) nanofibers and hydrolysed PSMA (H-PSMA) as additives(Elsevier, 2014) Pereira, V.R.; Isloor, A.M.; Bhat, K.U.; A.F., A.F.Polyaniline (PANI) nanofibers were used as hydrophilic additives to study their effect on the performance of polyvinylidene fluoride (PVDF) ultrafiltration (UF) membranes. PVDF UF membranes were prepared by the phase inversion method with hydrolyzed polystyrene-co-maleic anhydride (H-PSMA) and PANI nanofibers as additives. PANI nanofibers were synthesized by rapid mixing reaction and were used as a hydrophilic modifying agent with varying concentrations (0-1.5 wt.%) in the membranes. The synthesized PANI nanofibers were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and transmission electron microscope (TEM) analysis. Hydrolyzed PSMA was prepared by the hydrolysis of PSMA and was used as a novel pore forming additive. The addition of PANI nanofibers into the membranes increased the membrane hydrophilicity, porosity, water uptake and permeability. The membranes also showed good antifouling nature during BSA (bovine serum albumin) filtration when compared to the pristine membrane without PANI nanofibers. Membrane with 1.0 wt.% PANI content showed highest permeability among the synthesized membranes. The membrane having highest permeability was subjected to heavy metal ion rejection which showed high rejection of 98.52% and 97.38% for heavy metal ions Pb2+ and Cd2+ respectively. © 2014 Elsevier B.V.Item Mechanical properties and sliding wear behavior of jatropha seed cake waste/epoxy composites(Springer Japan, 2015) Shivamurty, B.; Murthy, K.; Joseph, P.C.; Rishi, K.; Bhat, K.U.; Anandhan, S.Jatropha seed cake particulate (JSCP)-reinforced epoxy composites were prepared by open mold resin casting method. The influence of JSCP on mechanical and dry sliding wear properties of epoxy was experimentally investigated as per the ASTM standards. Dry sliding wear test was conducted for these composites at a constant sliding distance of 500 m with different sliding velocities and applied loads by a pin-on-disc wear test machine. The results revealed that incorporation of JSCP decreased the specific wear rate and coefficient of friction while improving the mechanical properties. The composite reinforced with 40 wt% of JSCP exhibited better mechanical properties and wear behavior compared to the neat epoxy and other compositions of JSCP/epoxy composites. The results of this study indicate that jatropha seed cake powder can be used as biosolid lubricant filler for epoxy. © 2014, Springer Japan.Item Preparation and performance studies of polysulfone-sulfated nano-titania (S-TiO2) nanofiltration membranes for dye removal(Royal Society of Chemistry, 2015) Pereira, V.R.; Isloor, A.M.; Bhat, K.U.; A.F., A.F.; AlObaid, A.; Fun, H.-K.Polysulfone nanofiltration membranes containing sulfated nano-titania (S-TiO2) were fabricated, with the aim to enhance the membrane properties along with the possible rejection of Methylene Blue (MB) dye by membranes. Initially S-TiO2 was synthesized from nano TiO2 by the action of sulfuric acid. The synthesized S-TiO2 was characterized by Fourier Transform Infrared spectroscopy (FT-IR), Energy Dispersive Spectrophotometry (EDS) and Transmission Electron Microscopy (TEM) analysis. S-TiO2 was added in increasing concentrations into the membranes and its effect on the performance of the membranes was evaluated. The synthesized membranes were characterized by Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM). Polysulfone membranes containing S-TiO2 showed enhancement in properties in terms of hydrophilicity, water uptake, mechanical strength, improved pure water flux (PWF), antifouling nature and high Flux Recovery Ratio (FRR). The polysulfone membranes with S-TiO2 showed 99% rejection for BSA (Bovine Serum Albumin) protein molecules during BSA filtration. The prepared membranes were used for the removal of MB dye from aqueous solutions. A maximum of 90.4% rejection was obtained for MB for the membrane having 2.0 wt% of S-TiO2 under UV light radiation. This approach showed that polysulfone-S-TiO2 membranes displayed good efficiency for dye removal and can be effectively used for the removal of MB dye from aqueous solutions under suitable conditions. © The Royal Society of Chemistry.Item Improving Hot Corrosion Resistance of Cobalt Based Superalloy (Superco-605) Using HVOF Sprayed Oxide Alloy Powder Coating(Springer India sanjiv.goswami@springer.co.in, 2015) Jegadeeswaran, N.; Bhat, K.U.; Ramesh, M.R.Superco-605 is a cobalt based superalloy used widely in the hot section of gas turbines. During their operation, they are exposed to high temperature and molten salt environment, causing damage to the component due to hot corrosion. In this investigation, Superco-605 alloy was coated using a fused oxide alloy powder, $$ 10\,\% {\text{Al}}_{ 2} {\text{O}}_{ 3} + {\text{CoCrAlTaY}} $$10%Al2O3+CoCrAlTaY , using high velocity oxy-fuel process. Coating thickness was in the range of 260–280 µm and it was lamellar in nature. Uncoated and coated samples were subjected to cyclic hot corrosion tests at 800 °C in presence of molten salt environment of $$ {\text{Na}}_{ 2} {\text{SO}}_{ 4}{+}50\% {\text{V}}_{ 2} {\text{O}}_{ 5} $$Na2SO4+50%V2O5. Resistance to hot corrosion was investigated using thermogravimetric analysis, visual observations, X-ray diffractometry, scanning electron microscopy and energy dispersive X-ray spectroscopy. Both samples developed an oxide scale at the top. The uncoated Superco-605 exhibited intense spalling during hot corrosion cycles. The oxide scale on the coated substrate was thin compared to total thickness of the coating. There was a chromium depleted region close to the oxide top scale. An alumina rich layer at the interface of coating-substrate prevents penetration of oxygen into the substrate material. Based on the experimental results, it is concluded that the fused oxide alloy powder is effective in reducing hot corrosion tendency of Superco-605 alloy. © 2015, The Indian Institute of Metals - IIM.