Browsing by Author "Srinidhi, C.L."

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A Vessel Keypoint Detector for junction classification
(IEEE Computer Society, 2017) Srinidhi, C.L.; Rath, P.; Sivaswamy, J.
Retinal vessel keypoint detection and classification is a fundamental step in tracking the physiological changes that occur in the retina which is linked to various retinal and systemic diseases. In this paper, we propose a novel Vessel Keypoint Detector (VKD) which is derived from the projection of log-polar transformed binary patches around vessel points. VKD is used to design a two stage solution for junction detection and classification. In the first stage, the keypoints detected using VKD are refined using curvature orientation information to extract candidate junctions. True junctions from these candidates are identified in a supervised manner using a Random Forest classifier. In the next stage, a novel combination of local orientation and shape based features is extracted from the junction points and classified using a second Random Forest classifier. Evaluation results on five datasets show that the designed system is robust to changes in resolution and other variations across datasets, with average values of accuracy/sensitivity/specificity for junction detection being 0.78/0.79/0.75 and for junction classification being 0.87/0.85/0.88. Our system outperforms the state of the art method [1] by at least 11%, on the DRIVE and IOSTAR datasets. These results demonstrate the effectiveness of VKD for vessel analysis. Â© 2017 IEEE.
A visual attention guided unsupervised feature learning for robust vessel delineation in retinal images
(Elsevier Ltd, 2018) Srinidhi, C.L.; Aparna., P.; Rajan, J.
Background and objective: Accurate segmentation of retinal vessels from color fundus images play a significant role in early diagnosis of various ocular, systemic and neuro-degenerative diseases. Segmenting retinal vessels is challenging due to varying nature of vessel caliber, the proximal presence of pathological lesions, strong central vessel reflex and relatively low contrast images. Most existing methods mainly rely on carefully designed hand-crafted features to model the local geometrical appearance of vasculature structures, which often lacks the discriminative capability in segmenting vessels from a noisy and cluttered background. Methods: We propose a novel visual attention guided unsupervised feature learning (VA-UFL) approach to automatically learn the most discriminative features for segmenting vessels in retinal images. Our VA-UFL approach captures both the knowledge of visual attention mechanism and multi-scale contextual information to selectively visualize the most relevant part of the structure in a given local patch. This allows us to encode a rich hierarchical information into unsupervised filtering learning to generate a set of most discriminative features that aid in the accurate segmentation of vessels, even in the presence of cluttered background. Results: Our proposed method is validated on the five publicly available retinal datasets: DRIVE, STARE, CHASE_DB1, IOSTAR and RC-SLO. The experimental results show that the proposed approach significantly outperformed the state-of-the-art methods in terms of sensitivity, accuracy and area under the receiver operating characteristic curve across all five datasets. Specifically, the method achieved an average sensitivity greater than 0.82, which is 7% higher compared to all existing approaches validated on DRIVE, CHASE_DB1, IOSTAR and RC-SLO datasets, and outperformed even second-human observer. The method is shown to be robust to segmentation of thin vessels, strong central vessel reflex, complex crossover structures and fares well on abnormal cases. Conclusions: The discriminative features learned via visual attention mechanism is superior to hand-crafted features, and it is easily adaptable to various kind of datasets where generous training images are often scarce. Hence, our approach can be easily integrated into large-scale retinal screening programs where the expensive labelled annotation is often unavailable. © 2018 Elsevier Ltd
Automated Method for Retinal Artery/Vein Separation via Graph Search Metaheuristic Approach
(Institute of Electrical and Electronics Engineers Inc., 2019) Srinidhi, C.L.; Aparna., P.; Rajan, J.
Separation of the vascular tree into arteries and veins is a fundamental prerequisite in the automatic diagnosis of retinal biomarkers associated with systemic and neurodegenerative diseases. In this paper, we present a novel graph search metaheuristic approach for automatic separation of arteries/veins (A/V) from color fundus images. Our method exploits local information to disentangle the complex vascular tree into multiple subtrees, and global information to label these vessel subtrees into arteries and veins. Given a binary vessel map, a graph representation of the vascular network is constructed representing the topological and spatial connectivity of the vascular structures. Based on the anatomical uniqueness at vessel crossing and branching points, the vascular tree is split into multiple subtrees containing arteries and veins. Finally, the identified vessel subtrees are labeled with A/V based on a set of hand-crafted features trained with random forest classifier. The proposed method has been tested on four different publicly available retinal datasets with an average accuracy of 94.7%, 93.2%, 96.8%, and 90.2% across AV-DRIVE, CT-DRIVE, INSPIRE-AVR, and WIDE datasets, respectively. These results demonstrate the superiority of our proposed approach in outperforming the state-of-The-Art methods for A/V separation. © 1992-2012 IEEE.
Recent Advancements in Retinal Vessel Segmentation
(Springer New York LLC barbara.b.bertram@gsk.com, 2017) Srinidhi, C.L.; Aparna., P.; Rajan, J.
Retinal vessel segmentation is a key step towards the accurate visualization, diagnosis, early treatment and surgery planning of ocular diseases. For the last two decades, a tremendous amount of research has been dedicated in developing automated methods for segmentation of blood vessels from retinal fundus images. Despite the fact, segmentation of retinal vessels still remains a challenging task due to the presence of abnormalities, varying size and shape of the vessels, non-uniform illumination and anatomical variability between subjects. In this paper, we carry out a systematic review of the most recent advancements in retinal vessel segmentation methods published in last five years. The objectives of this study are as follows: first, we discuss the most crucial preprocessing steps that are involved in accurate segmentation of vessels. Second, we review most recent state-of-the-art retinal vessel segmentation techniques which are classified into different categories based on their main principle. Third, we quantitatively analyse these methods in terms of its sensitivity, specificity, accuracy, area under the curve and discuss newly introduced performance metrics in current literature. Fourth, we discuss the advantages and limitations of the existing segmentation techniques. Finally, we provide an insight into active problems and possible future directions towards building successful computer-aided diagnostic system. © 2017, Springer Science+Business Media New York.
A Vessel Keypoint Detector for junction classification
(2017) Srinidhi, C.L.; Rath, P.; Sivaswamy, J.
Retinal vessel keypoint detection and classification is a fundamental step in tracking the physiological changes that occur in the retina which is linked to various retinal and systemic diseases. In this paper, we propose a novel Vessel Keypoint Detector (VKD) which is derived from the projection of log-polar transformed binary patches around vessel points. VKD is used to design a two stage solution for junction detection and classification. In the first stage, the keypoints detected using VKD are refined using curvature orientation information to extract candidate junctions. True junctions from these candidates are identified in a supervised manner using a Random Forest classifier. In the next stage, a novel combination of local orientation and shape based features is extracted from the junction points and classified using a second Random Forest classifier. Evaluation results on five datasets show that the designed system is robust to changes in resolution and other variations across datasets, with average values of accuracy/sensitivity/specificity for junction detection being 0.78/0.79/0.75 and for junction classification being 0.87/0.85/0.88. Our system outperforms the state of the art method [1] by at least 11%, on the DRIVE and IOSTAR datasets. These results demonstrate the effectiveness of VKD for vessel analysis. � 2017 IEEE.